反应条件
1: diisobutylaluminium hydride / toluene / -78 - 0 °C / Inert atmosphere 2: triethylamine; methanesulfonyl chloride / dichloromethane / 5 h / 0 - 25 °C 3: hydrogen bromide / water / 15 h / 80 °C 4: toluene / 3 h / 0 - 20 °C 5: potassium carbonate / N,N-dimethyl-formamide / 6 h / 70 - 75 °C 6: sulfuric acid / acetonitrile / 3 h / 50 - 60 °C View Scheme
参考文献
YUHAN CORPORATION; JU, Hyun; JOUNG, Sang-Sun; YI, Hyun-Jik; KHOO, Ja-Heouk; LIM, Jong-Chul; KIM, Jae-Gyu
Patent: WO2012/2741 A2, 2012 ;
WO 2012/002741 A2