5-羧酸-2-噻吩甲酸甲酯合成路线 （共 10 条）
反应条件
hydrogenchloride; sodium hydroxide in 1,4-dioxane; methanol; water
参考文献
Pfizer Products Inc.
Patent: WO2004/817 A2, 2003 ;
Location in patent: Page 99 ;
WO 2004/000817 A2
反应条件
sodium carbonate in DMF (N,N-dimethyl-formamide) T=20°C;
参考文献
NISSAN CHEMICAL INDUSTRIES, LTD.
Patent: WO2004/108683 A1, 2004 ;
Location in patent: Page 548 ;
反应条件
jones reagent in acetone 1 h; Ambient temperature;
参考文献
Goddard
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 1 p. 17 - 28
反应条件
in ethyl acetate; acetone
参考文献
Pfizer Inc.
Patent: US5047554 A1, 1991 ;
US 5047554 A
反应条件
1: 88 percent / Na2CO3 / dimethylformamide / Ambient temperature 2: 73 percent / Jones reagent / acetone / 1 h / Ambient temperature View Scheme
参考文献
Frizler, Maxim; Schmitz, Janina; Schulz-Fincke, Anna-Christina; Guetschow, Michael
Journal of Medicinal Chemistry, 2012 , vol. 55, # 12 p. 5982 - 5986
反应条件
potassium permanganate; acetone
参考文献
Birkinshaw; Chaplen
Biochemical Journal, 1955 , vol. 60, p. 255,259
反应条件
1: water; mercury (II)-iodide; potassium iodide / Behandeln mit wss. Natronlauge 2: diethyl ether 3: potassium permanganate; acetone View Scheme
参考文献
Birkinshaw; Chaplen
Biochemical Journal, 1955 , vol. 60, p. 255,259
反应条件
1: diethyl ether 2: potassium permanganate; acetone View Scheme
参考文献
Birkinshaw; Chaplen
Biochemical Journal, 1955 , vol. 60, p. 255,259
反应条件
1: SOCl2 / 1.5 h / Heating
2: 2) HBr(g) / 1) ether, 0 deg C, overnight, 2) 20 min
View Scheme
参考文献
Goddard
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 1 p. 17 - 28
参考文献
Birkinshaw; Chaplen
Biochemical Journal, 1955 , vol. 60, p. 255,259
