3-羟基-3-甲基谷氨酸合成路线 （共 56 条）
反应条件
nitric acid T=55 - 60°C; in the presence of nitrogen tetroxide; Product distributionMechanism;
参考文献
Sargsyan, M. S.; Mkrtumyan, S. A.; Gevorkyan, A. A.
Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, # 10 p. 1963 - 1967
Zhurnal Organicheskoi Khimii, 1987 , vol. 23, # 10 p. 2220 - 2224
反应条件
potassium hydroxide in methanol 16 h; Ambient temperature; Product distribution;
参考文献
Bollerner, Yu. S.; Abdullaev, N. D.; Gorovits, M. B.; Abubakirov, N. K.
Chemistry of Natural Compounds, 1983 , vol. 19, # 3 p. 186 - 190
Khimiya Prirodnykh Soedinenii, 1983 , vol. 19, # 3 p. 197 - 201
反应条件
nitric acid T=55 - 60°C; in the presence of nitrogen tetroxide; Product distributionMechanism;
参考文献
Sargsyan, M. S.; Mkrtumyan, S. A.; Gevorkyan, A. A.
Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, # 10 p. 1963 - 1967
Zhurnal Organicheskoi Khimii, 1987 , vol. 23, # 10 p. 2220 - 2224
参考文献
Sorokin
Journal fuer Praktische Chemie (Leipzig), 1881 , vol. <2>23, p. 276
反应条件
1: Heating 2: xylene / Heating 4: 2.) Ag2O, MgSO4 / 1.) xylene, reflux 5: HBr, HOAc View Scheme
参考文献
Ahmed, Salman A.; Bardshiri, Esfandiar; McIntyre, C. Rupert; Simpson, Thomas J.
Australian Journal of Chemistry, 1992 , vol. 45, # 1 p. 249 - 274
反应条件
thionyl chloride in diethyl ether 16 h; Ambient temperature;
参考文献
Brown, Kenneth; Devlin, J. Alastair; Robins, David J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 8 p. 1819 - 1824
反应条件
dicyclohexyl-carbodiimide in acetone T=46°C; 3 h;
参考文献
Lewer, Paul; MacMillan, Jake
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 7 p. 1417 - 1420
参考文献
Lewer, Paul; MacMillan, Jake
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 7 p. 1417 - 1420
反应条件
1: 100 percent / 2 h / 60 °C 2: 100 percent / xylene / 20 h / Heating 3: 83 percent / diethyl ether / 1 h / Ambient temperature 4: 2.) Ag2O, MgSO4 / 1.) xylene, reflux, 5 d, 2.) xylene, RT, 12 h 5: 100 percent / 48percent HBr / acetic acid / 5 h / Heating View Scheme
参考文献
Ahmed, Salman A.; Bardshiri, Esfandiar; Simpson, Thomas J.
Journal of the Chemical Society, Chemical Communications, 1987 , p. 883 - 884
反应条件
1: 89 percent / thionyl chloride / diethyl ether / 16 h / Ambient temperature 2: pyridine / diethyl ether / 10 h / Ambient temperature 3: 2.) triphenylphosphine, 2,2'-dithiodipyridine / 1.) chloroform, RT, 12 h, 2.) chloroform, 8 h, reflux, 12 h 4: 100 percent / hydrogen / platinum oxide / acetic acid / 24 h 5: 76 percent / liquid ammonia, sodium / methanol View Scheme
参考文献
Brown, Kenneth; Devlin, J. Alastair; Robins, David J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 8 p. 1819 - 1824
