3-羟基-3-甲基谷氨酸合成路线 （共 56 条）
反应条件
in acetic acid n-butyl ester; nitric acid
参考文献
Laboratori Guidotti SpA
Patent: US4966993 A1, 1990 ;
参考文献
Roussel Uclaf
Patent: US4467108 A1, 1984 ;
反应条件
hydrogenchloride in water; ethyl acetate
参考文献
Roussel Uclaf
Patent: US4467108 A1, 1984 ;
反应条件
ethyl acetate durch Ozonisierung und Oxydation des gebildeten Dialdehyds mit H2O2 in Essigsaeure und verd.H2SO4;
参考文献
Tschesche,R.; Machleidt,H.
Justus Liebigs Annalen der Chemie, 1960 , vol. 631, p. 61 - 76
Full Text Show Details
Rabinowitz
Biochemical Preparations, 1958 , vol. 6, p. 25
反应条件
nitric acid; sodium nitrite T=35 - 40°C; 5 h;
参考文献
Sargsyan, M. S.; Manukyan, A. T.; Mkrtumyan, S. A.; Gevorkyan, A. A.
Chemistry of Natural Compounds, 1990 , vol. 26, # 1 p. 24 - 25
Khimiya Prirodnykh Soedinenii, 1990 , # 1 p. 31 - 32
反应条件
barium dihydroxide in water 1 h; Heating;
参考文献
Brown, Kenneth; Devlin, J. Alastair; Robins, David J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 8 p. 1819 - 1824
反应条件
1: pyridine / diethyl ether / 10 h / Ambient temperature 2: 2.) triphenylphosphine, 2,2'-dithiodipyridine / 1.) chloroform, RT, 12 h, 2.) chloroform, 8 h, reflux, 12 h 3: 100 percent / hydrogen / platinum oxide / acetic acid / 24 h 4: 74 percent / 1M-barium hydroxide / H2O / 1 h / Heating View Scheme
参考文献
Brown, Kenneth; Devlin, J. Alastair; Robins, David J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 8 p. 1819 - 1824
反应条件
1: 2.) triphenylphosphine, 2,2'-dithiodipyridine / 1.) chloroform, RT, 12 h, 2.) chloroform, 8 h, reflux, 12 h 2: 100 percent / hydrogen / platinum oxide / acetic acid / 24 h 3: 74 percent / 1M-barium hydroxide / H2O / 1 h / Heating View Scheme
参考文献
Brown, Kenneth; Devlin, J. Alastair; Robins, David J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 8 p. 1819 - 1824
参考文献
Adams; Van Duuren
Journal of the American Chemical Society, 1953 , vol. 75, p. 2377
反应条件
1: 100 percent / hydrogen / platinum oxide / acetic acid / 24 h 2: 74 percent / 1M-barium hydroxide / H2O / 1 h / Heating View Scheme
参考文献
Brown, Kenneth; Devlin, J. Alastair; Robins, David J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 8 p. 1819 - 1824
