2-(TETRAHYDROPYRAN-2-YLOXY)PHENYLBORONIC ACID合成路线 （共 4 条）
反应条件
1: 395 mg / aq. Na2CO3 / Pd(PPh3)4 / toluene; ethanol / 15 h / 80 °C 2: 76 percent / p-TsOH / methanol / 1.5 h View Scheme
参考文献
Blume, Florian; Zemolka, Saskia; Fey, Thorsten; Kranich, Remo; Schmalz, Hans-Guenther
Advanced Synthesis and Catalysis, 2002 , vol. 344, # 8 p. 868 - 883
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 20°C; 0.75 h;
2: With tri-isopropoxy-borane in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Kranich, Remo; Busemann, Anke S.; Bock, Daniel; Schroeter-Maas, Sabine; Beyer, Diana; Heinemann, Bo; Meyer, Michael; Schierhorn, Katrin; Zahlten, Rainer; Wolff, Gerhard; Aydt, Ewald M.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 6 p. 1101 - 1115
反应条件
1.1: PPTS / CH2Cl2 / 20 °C
2.1: n-BuLi / hexane; tetrahydrofuran / 0.75 h / -78 - 20 °C
2.2: triisopropyl borate / hexane; tetrahydrofuran / -78 - 20 °C
View Scheme
参考文献
Kranich, Remo; Busemann, Anke S.; Bock, Daniel; Schroeter-Maas, Sabine; Beyer, Diana; Heinemann, Bo; Meyer, Michael; Schierhorn, Katrin; Zahlten, Rainer; Wolff, Gerhard; Aydt, Ewald M.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 6 p. 1101 - 1115
反应条件
1.1: PPTS / CH2Cl2 / 20 °C
2.1: n-BuLi / hexane; tetrahydrofuran / 0.75 h / -78 - 20 °C
2.2: triisopropyl borate / hexane; tetrahydrofuran / -78 - 20 °C
View Scheme
参考文献
Kranich, Remo; Busemann, Anke S.; Bock, Daniel; Schroeter-Maas, Sabine; Beyer, Diana; Heinemann, Bo; Meyer, Michael; Schierhorn, Katrin; Zahlten, Rainer; Wolff, Gerhard; Aydt, Ewald M.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 6 p. 1101 - 1115
