2-(3-甲氧基苯基)乙醇合成路线 （共 48 条）
参考文献
Colonge; Rochas
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1946 , vol. 223, p. 403
Bulletin de la Societe Chimique de France, 1948 , p. 818,821
反应条件
molecular sieve; pyridinium chlorochromate in dichloromethane T=20°C; 8 h;
参考文献
Fernandes, Rodney A.; Kumar, Pradeep
Tetrahedron Letters, 2003 , vol. 44, # 6 p. 1275 - 1278
反应条件
1: 80 percent / Br2 / CHCl3 / 1 h 2: 91 percent / Ph3P, imidazole, I2 / CH2Cl2 / 1 h 3: 97 percent / LDA / tetrahydrofuran; various solvent(s) / 1.) -78 deg C, 1h, 2.) -78 deg C, 1 h, -78 deg C to 0 deg C, 2 h 4: 80 percent / LDA / tetrahydrofuran; various solvent(s) / 1.) -78 deg C, 2 h, 2.) -78 deg C, 1h 5: 1.) t-BuLi, 2.) n-Bu4NH2PO4 / 1.) THF, -78 deg C, 1 h, 2.) H2O, reflux, 12 h 6: NaOEt / ethanol / 24 h / Heating View Scheme
参考文献
Snyder, Lawrence; Meyers, A. I.
Journal of Organic Chemistry, 1993 , vol. 58, # 26 p. 7507 - 7515
反应条件
1: I2, PPh3, imidazole 2: Na / ethanol 3: 1.) PIFA, BF3*Et2O, 2.) MeNH2 / 1.) CH2Cl2, -78 deg C, 30 min, 2.) CH2Cl2, H2O, r.t., 30 min 4: 88 percent / N-chlorosuccinimide View Scheme
参考文献
Kita, Yasuyuki; Egi, Masahiro; Takada, Takeshi; Tohma, Hirofumi
Synthesis, 1999 , # 5 p. 885 - 897
反应条件
potassium hydroxide T=160°C; P=15 - 16 Torr;
参考文献
Miklhail, Gamal; Demuth, Martin
Helvetica Chimica Acta, 1983 , vol. 66, # 7 p. 2362 - 2368
反应条件
hydrogen bromide; acetic acid
参考文献
Khafagy,E.Z.; Lambooy,J.P.
Journal of Medicinal Chemistry, 1966 , vol. 9, p. 936 - 940
反应条件
hydrogenchloride; sodium hydroxide 1) -8 to -12 deg C, 1 h, 2) acetone, reflux, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Unterhalt; Joestingmeier
Pharmazie, 1996 , vol. 51, # 9 p. 641 - 644
反应条件
1: 5 percent / tributylhexadecylphosphonium bromide; 47 percent HBr / 1.5 h / Heating 2: 78 percent / ethanol / 3 h / Heating View Scheme
参考文献
Hashima, Hirofumi; Hayashi, Masahiko; Kamano, Yoshiaki; Sato, Nobuhiro
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 7 p. 1757 - 1766
反应条件
Amberlyst 15 12 h; Reflux;
参考文献
Tetrahedron Letters, , vol. 54, # 37 p. 5004 - 5006
反应条件
potassium hydroxide in dimethyl sulfoxide
参考文献
Tetrahedron: Asymmetry, , vol. 3, # 6 p. 775 - 784
