3,7-二甲基-6-辛烯酸合成路线 （共 32 条）
反应条件
pyridine; lithium tri(t-butoxy)aluminum hydride; N,N-dimethylchloromethyleniminium chloride; copper(l) iodide 1) CH3CN - THF, -30 deg C, 1 h, 2) -78 deg C, 10 min; dimethylchloromethyleniminium chloride is prepared previously in situ from oxalylchloride and DMF.;
参考文献
Fujisawa, Tamotsu; Mori, Toshiki; Tsuge, Shoichi; Sato, Toshio
Tetrahedron Letters, 1983 , vol. 24, # 14 p. 1543 - 1546
反应条件
1: H2 / Pd/C 2: LiAlH4 / diethyl ether / 20 °C View Scheme
参考文献
Wong, Man-Kin; Chung, Nga-Wai; He, Lan; Yang, Dan
Journal of the American Chemical Society, 2003 , vol. 125, # 1 p. 158 - 162
反应条件
1: SOCl2 / pyridine
2: 1. BF3*OEt2, CH2Cl2, room temperature, 2 day 2. K2CO3, methanol, room temperature, 3 h
View Scheme
参考文献
Barczak, Nicholas T.; Jarvo, Elizabeth R.
Chemistry - A European Journal, 2011 , vol. 17, # 46 p. 12912 - 12916
反应条件
1: H2 / Pd/C
2: LiAlH4 / diethyl ether / 20 °C
3: pyridine / 0 °C
4: DMSO / 60 °C
5: NaOH; H2O / ethanol / Heating
View Scheme
参考文献
Wong, Man-Kin; Chung, Nga-Wai; He, Lan; Yang, Dan
Journal of the American Chemical Society, 2003 , vol. 125, # 1 p. 158 - 162
参考文献
Schwartz; Curran
Journal of the American Chemical Society, 1990 , vol. 112, # 25 p. 9272 - 9284
反应条件
1: thionyl chloride / dimethylformamide / 1 h / 30 °C
2: 1 h / 20 °C
View Scheme
参考文献
Odinokov, V. N.; Kukovinets, O. S.; Sakharova, N. I.; Tolstikov, G. A.
Russian Journal of Organic Chemistry, 1993 , vol. 29, # 1.1 p. 24 - 30
Zhurnal Organicheskoi Khimii, 1993 , vol. 29, # 1 p. 31 - 38
反应条件
1: 63 percent / DMAP; DCC / CH2Cl2 / 12 h / 0 °C
2: 34 percent Spectr. / MAP / toluene / 3 h / Irradiation
View Scheme
参考文献
McCarroll, Andrew J.; Walton, John C.
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 12 p. 2399 - 2409
反应条件
1: H2 / Pd/C
2: LiAlH4 / diethyl ether / 20 °C
3: pyridine / 0 °C
View Scheme
参考文献
Wong, Man-Kin; Chung, Nga-Wai; He, Lan; Yang, Dan
Journal of the American Chemical Society, 2003 , vol. 125, # 1 p. 158 - 162
反应条件
hydrogen in ethanol
T=20°C; P=760.051 Torr; 2 h; chemoselective reaction;
参考文献
Kantam, Mannepalli Lakshmi; Kishore, Ramineni; Yadav, Jagjit; Sudhakar, Medak; Venugopal, Akula
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 4 p. 663 - 669
反应条件
1.1: carbonyl diimidazole / CH2Cl2 / 0.75 h
1.2: CH2Cl2
2.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C
2.2: tetrahydrofuran; hexane / -78 - 20 °C
View Scheme
参考文献
Kapdi, Anant R.; Fairlamb, Ian J. S.
New Journal of Chemistry, 2013 , vol. 37, # 4 p. 961 - 964
