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乙二醇
甲醛
63148-62-9
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二甲基亚砜
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471-34-1
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罗沙布林
合成路线
（共 8 条）
24340-76-9
3-甲基异噻唑-5-胺
→
反应条件
501948-05-6
罗沙布林
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in tetrahydrofuran T=-30 - -25°C; 2 h; Inert atmosphere;
参考文献
Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun
Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250
24340-76-9
3-甲基异噻唑-5-胺
+
79-37-8
草酰氯
+
501948-43-2
→
反应条件
501948-05-6
罗沙布林
反应条件
in tetrahydrofuran; diethyl ether
参考文献
SBR Pharmaceuticals Corp.
Patent: US2003/153759 A1, 2003 ;
104-85-8
对甲苯腈
→
反应条件
501948-05-6
罗沙布林
反应条件
1.1: diisopropylamine; n-butyllithium; N,N'-dimethyl-N,N'-propyleneurea / tetrahydrofuran; water / 1.67 h / -78 °C / |Inert atmosphere 1.2: 1.5 h / -78 °C / |Inert atmosphere 2.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 h / 60 °C 3.1: triethylamine; copper(l) chloride / N,N-dimethyl acetamide / 3 h / 20 - 130 °C 4.1: tetrahydrofuran / -50 - -40 °C / |Inert atmosphere 5.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 2 h / -30 - -25 °C / |Inert atmosphere View Scheme
参考文献
Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun
Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250
501948-45-4
→
反应条件
501948-05-6
罗沙布林
反应条件
1: triethylamine; copper(l) chloride / N,N-dimethyl acetamide / 3 h / 20 - 130 °C 2: tetrahydrofuran / -50 - -40 °C / |Inert atmosphere 3: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 2 h / -30 - -25 °C / |Inert atmosphere View Scheme
参考文献
Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun
Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250
501948-43-2
→
反应条件
501948-05-6
罗沙布林
反应条件
1: tetrahydrofuran / -50 - -40 °C / |Inert atmosphere 2: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 2 h / -30 - -25 °C / |Inert atmosphere View Scheme
参考文献
Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun
Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250
501948-42-1
→
反应条件
501948-05-6
罗沙布林
反应条件
1: borane-THF / acetonitrile; methanol / 1 h / 50 °C 2: tetrahydrofuran / -50 - -40 °C / |Inert atmosphere 3: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 2 h / -30 - -25 °C / |Inert atmosphere View Scheme
参考文献
Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun
Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250
1443-80-7
对氰基苯乙酮
→
反应条件
501948-05-6
罗沙布林
反应条件
1.1: bromine / ethyl acetate / 1 h / 20 °C 1.2: 2.5 h / 0 - 20 °C 2.1: N,N-dimethyl-formamide; dimethyl sulfate / N,N-dimethyl-formamide / 0.25 h / 20 °C / |Inert atmosphere 2.2: |Inert atmosphere 3.1: borane-THF / acetonitrile; methanol / 1 h / 50 °C 4.1: tetrahydrofuran / -50 - -40 °C / |Inert atmosphere 5.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 2 h / -30 - -25 °C / |Inert atmosphere View Scheme
参考文献
Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun
Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250
109-06-8
2-甲基吡啶
→
反应条件
501948-05-6
罗沙布林
反应条件
1.1: bromine / ethyl acetate / 1 h / 20 °C 1.2: 2.5 h / 0 - 20 °C 2.1: N,N-dimethyl-formamide; dimethyl sulfate / N,N-dimethyl-formamide / 0.25 h / 20 °C / |Inert atmosphere 2.2: |Inert atmosphere 3.1: borane-THF / acetonitrile; methanol / 1 h / 50 °C 4.1: tetrahydrofuran / -50 - -40 °C / |Inert atmosphere 5.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 2 h / -30 - -25 °C / |Inert atmosphere View Scheme
参考文献
Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun
Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250
