5-甲基-3-((三甲基甲硅烷基)乙炔)吡啶-2-胺合成路线 （共 5 条）
反应条件
triethylamine; triphenylphosphine; palladium diacetate in N,N-dimethyl-formamide T=50°C; 16 h;
参考文献
Abbiati, Giorgio; Arcadi, Antonio; Marinelli, Fabio; Rossi, Elisabetta
Synthesis, 2002 , # 13 p. 1912 - 1916
反应条件
1,4-diaza-bicyclo[2.2.2]octane; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide T=110°C; 16 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/4117 A1, 2008 ;
Location in patent: Page/Page column 106-107 ;
反应条件
pyrrolidine T=20 - 100°C; Sonogashira coupling; Microwave irradiation;
参考文献
Carpita, Adriano; Ribecai, Arianna; Stabile, Paolo
Tetrahedron, 2010 , vol. 66, # 35 p. 7169 - 7178
反应条件
potassium tert-butylate in NMP (1-methyl-2-oxopyrrolidine) T=20°C; RefluxInert atmosphere;
参考文献
US2009/253679 A1, ;
Page/Page column 41 ;
反应条件
water; sodium hydroxide in methanol
T=20°C;
参考文献
Carpita, Adriano; Ribecai, Arianna; Stabile, Paolo
Tetrahedron, 2010 , vol. 66, # 35 p. 7169 - 7178
