Alpha-苯基-2-吡啶基乙腈合成路线 （共 23 条）
反应条件
1: 1.) KOH / 1.) DMSO, RT, 50 min, 2.) DMSO, RT 2 h 2: 1.) titanium tetrachloride, 2.) NaBH4 / 1.) CH2Cl2, 5 deg C, 0.5 h, 2.) CH2Cl2, MeOH, from 10 deg C to RT, 50 min 3: 18.9 g / H2SO4 / acetic acid / 2 h / 90 °C View Scheme
参考文献
Oyasu, Hitoshi; Nagano, Masanobu; Akahane, Atsushi; Tomoi, Masaaki; Tada, Toshiji; Matsuo, Masaaki
Journal of Medicinal Chemistry, 1994 , vol. 37, # 9 p. 1378 - 1381
反应条件
1: 12 N HCl / 15 h / Ambient temperature 2: H2 / 5percent Pt/C / acetic acid / 10 h / 1551.4 - 2068.6 Torr 3: 1.) 6N HCl, 2.) 50percent KOH / 1.) reflux, 6 h, 2.) reflux, 4 d View Scheme
参考文献
Deutsch, Howard M.; Shi, Qing; Gruszecka-Kowalik, Ewa; Schwer, Margaret M.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 6 p. 1201 - 1209
反应条件
sodium amide; toluene
参考文献
Bristol Labor. Inc.
Patent: US2823233 , 1954 ;
