(E)-5-[2-(3-羟基-4-甲氧基苯基)乙烯基]-1,3-苯二酚合成路线 （共 13 条）
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 °C 1.2: 54 percent / tetrahydrofuran; hexane / 20 °C 2.1: 16 percent / AlCl3; N,N-dimethylaniline / CH2Cl2 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 16 p. 3546 - 3554
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 °C 1.2: 54 percent / tetrahydrofuran; hexane / 20 °C 2.1: 16 percent / AlCl3; N,N-dimethylaniline / CH2Cl2 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 16 p. 3546 - 3554
反应条件
1: H2 / Pd-C / ethanol 2: (i) PBr3, THF, benzene, (ii) /BRN= 385737/, Py, (iii) /BRN= 610776/, benzene 3: TsOH / methanol 4: (i) PhLi, Et2O, (ii) /BRN= 1961114/, (iii) H2O View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 750, p. 109 - 127
反应条件
hydrogenchloride in methanol 9 h; Heating;
参考文献
Phytochemistry (Elsevier), , vol. 39, # 4 p. 895 - 898
反应条件
1: Py / benzene 2: (i) PhLi, Et2O, (ii) /BRN= 1961114/, (iii) H2O View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 750, p. 109 - 127
反应条件
sulfuric acid in water; acetone 4 h; Heating;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 32, # 9 p. 3501 - 3517
反应条件
1: (i) PBr3, THF, benzene, (ii) /BRN= 385737/, Py, (iii) /BRN= 610776/, benzene 2: TsOH / methanol 3: (i) PhLi, Et2O, (ii) /BRN= 1961114/, (iii) H2O View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 750, p. 109 - 127
反应条件
1: TsOH / methanol 2: (i) PhLi, Et2O, (ii) /BRN= 1961114/, (iii) H2O View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 750, p. 109 - 127
反应条件
triethanolamine; palladium diacetate T=100°C; Heck Reaction; 24 h; Inert atmosphere;
参考文献
Archiv der Pharmazie, , vol. 346, # 7 p. 499 - 503
反应条件
(i) PhLi, Et2O, (ii) /BRN= 1961114/, (iii) H2O; Multistep reaction;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 750, p. 109 - 127
