5-氟-2'-脱氧脲核苷合成路线 （共 43 条）
反应条件
phospholipase D-P in chloroform T=45°C; 6 h; 250 mM CaCl2, 200 mM acetate buffer (pH 6.0);
参考文献
Shuto, Satoshi; Ueda, Shigeru; Imamura, Shigeyuki; Fukukawa, Kiyofumi; Matsuda, Akira; Ueda, Tohru
Tetrahedron Letters, 1987 , vol. 28, # 2 p. 199 - 202
反应条件
Candida antarctica lipase B in acetone T=40°C; 4 h; Enzymatic reaction; regioselective reaction;
参考文献
Li, Ning; Zong, Min-Hua; Ma, Ding
European Journal of Organic Chemistry, 2008 , # 32 p. 5375 - 5378
反应条件
1: 59 percent / methyltriphenoxyphosphonium iodide / dimethylformamide / 1 h / Ambient temperature
2: 79 percent / triethylamine, hydrogen / palladium on carbon / methanol / 0.83 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Cook, A. F.; Holman, M. J.; Kramer, M. J.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 852 - 857
