5-氟-2'-脱氧脲核苷合成路线 （共 43 条）
反应条件
porcine liver esterase in water T=37°C; pH=7.00; enzyme concentration dependence; Rate constant;
参考文献
Kawaguchi; Suzuki; Nakahara; Nambu; Nagai
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 1 p. 301 - 307
反应条件
thymidine phosphorylase from Escherichia coli in phosphate buffer T=35°C; pH=7.0; 2 h; Kinetics;
参考文献
Hatano, Akihiko; Harano, Aiko; Kirihara, Masayuki
Chemistry Letters, 2006 , vol. 35, # 2 p. 232 - 233
反应条件
in acetic acid Yield given. Further byproducts given. Yields of byproduct given;
参考文献
Visser, Gerard W. M.; Herder, Renella E.; Noordhuis, Paul; Zwaagstra, Oene; Herscheid, Jacobus D. M.; Kanter, Frans J. J. de
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 2547 - 2554
反应条件
in methanol; water T=20°C; Irradiationother 3-substituted 5-fluorouridine and 2'-deoxy-5-fluorouridine, var. solvents saturated with oxygen or nitrogen; Product distributionMechanism;
参考文献
Kuroda; Hisamura; Matsukuma; Nishikawa; Morimoto; Ashizawa; Nakamizo; Otsuji
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 5 p. 1133 - 1142
反应条件
esterase (porcine liver) T=37.5°C; 2 h; In vitro drug release studies: enzymatic and nonenzymatic processes; var. reaction cond.; Product distribution;
参考文献
Onishi; Kawaguchi; Nagai
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 8 p. 3370 - 3374
反应条件
in methanol; water Ambient temperatureIrradiationother 5'-O-substituted 2'-deoxy-5-fluorouridine, var. solvents (saturated or no with nitrous oxide); Product distributionMechanism;
参考文献
Kuroda; Hisamura; Nakamizo; Otsuji
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 5 p. 1143 - 1147
反应条件
phosphate buffer; peptide deformylase from E. coli deformylation; intramolecular cyclization; pH=7.4; Enzyme kinetics;
参考文献
Wei, Yaoming; Pei, Dehua
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 10 p. 1073 - 1076
反应条件
phosphate buffer; peptide deformylase from E. coli deformylation; intramolecular cyclization; pH=7.4; Enzyme kinetics;
参考文献
Wei, Yaoming; Pei, Dehua
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 10 p. 1073 - 1076
反应条件
phosphate buffer; peptide deformylase from E. coli deformylation; cyclization; pH=7.4; Enzyme kinetics;
参考文献
Wei, Yaoming; Pei, Dehua
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 10 p. 1073 - 1076
反应条件
phosphate buffer; peptide deformylase from E. coli deformylation; intramolecular cyclization; pH=7.4; Enzyme kinetics;
参考文献
Wei, Yaoming; Pei, Dehua
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 10 p. 1073 - 1076
