5-氟-2'-脱氧脲核苷合成路线 （共 43 条）
反应条件
sodium methylate in methanol T=20°C; 3 h;
参考文献
Yang, Fei; Zhu, Yugen; Yu, Biao
Chemical Communications, 2012 , vol. 48, # 56 p. 7097 - 7099
反应条件
2-hydroxyethanethiol; manganese (II) chloride; phosphopentomutase; thimidine phosphorylase in various solvent(s) T=45°C; pH=7; 2.25 h;
参考文献
Taverna-Porro, Marisa; Bouvier, Leon A.; Pereira, Claudio A.; Montserrat, Javier M.; Iribarren, Adolfo M.
Tetrahedron Letters, 2008 , vol. 49, # 16 p. 2642 - 2645
反应条件
methanol; barium dimethoxide
参考文献
Aoyama
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 6 p. 2073 - 2077
反应条件
thymidine phosphorylase from Escherichia coli (E.C. 2.4.2.4) immobilized on Sepabeads EC-EP® in aq. phosphate buffer T=20°C; pH=7.5; 3 h; Enzymatic reaction; Catalytic behavior; Reagent/catalystpH-valueConcentration;
参考文献
Serra, Immacolata; Bavaro, Teodora; Cecchini, Davide A.; Daly, Simona; Albertini, Alessandra M.; Terreni, Marco; Ubiali, Daniela
Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 95, p. 16 - 22
反应条件
thymidine phosphorylase in aq. phosphate buffer T=37°C; pH=6.8; 0.2 h; Enzymatic reaction;
参考文献
Hatano, Akihiko; Kurosu, Masayuki; Yonaha, Susumu; Okada, Munehiro; Uehara, Sanae
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 40 p. 6900 - 6905
反应条件
methanol; barium dimethoxide
参考文献
Hoffer et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 4112
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Hoffmann-La Roche
Patent: US2949451 , 1959 ;
反应条件
phosphate buffer in N,N-dimethyl-formamide T=25°C; 18 h; enzym: Subtilisin;
参考文献
Uemura, Atsuhiko; Nozaki, Kenji; Yamashita, Jun-ichi; Yasumoto, Mitsugi
Tetrahedron Letters, 1989 , vol. 30, # 29 p. 3819 - 3820
反应条件
phosphate buffer in N,N-dimethyl-formamide T=25°C; 18 h; enzym: Pseudomonas fluorescens;
参考文献
Uemura, Atsuhiko; Nozaki, Kenji; Yamashita, Jun-ichi; Yasumoto, Mitsugi
Tetrahedron Letters, 1989 , vol. 30, # 29 p. 3819 - 3820
反应条件
1: acetic acid 2: triethylamine / 0.5 h / 70 °C View Scheme
参考文献
Visser, Gerard W. M.; Herder, Renella E.; Noordhuis, Paul; Zwaagstra, Oene; Herscheid, Jacobus D. M.; Kanter, Frans J. J. de
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 2547 - 2554
反应条件
T=37°C; 16 h; alginate gel-entrapped cells of auxotrophic thymine-dependent strain of E. coli, ammonium acetate buffer pH 5.8;
参考文献
Votruba, Ivan; Holy, Antonin; Dvorakova, Hana; Guenter, Jaroslav; Hockova, Dana; et al.
Collection of Czechoslovak Chemical Communications, 1994 , vol. 59, # 10 p. 2303 - 2330
