5-氯-2-脱氧尿嘧啶核苷合成路线 （共 6 条）
反应条件
sodium methylate in methanol 1 h; Ambient temperature;
参考文献
Asakura, Jun-ichi; Robins, Morris J.
Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4928 - 4933
反应条件
N-chloro-succinimide; [MoeMim][Ms] T=50°C; 20 h;
参考文献
Kumar, Vineet; Yap, Jeremy; Muroyama, Andrew; Malhotra, Sanjay V.
Synthesis, 2009 , # 23 art. no. M01709SS, p. 3957 - 3962
反应条件
1: N-chlorosuccinimide / acetic acid / 80 °C 2: ammonia / methanol / Ambient temperature View Scheme
参考文献
Yueh, Han; Yu, Hongchuan; Theile, Christopher S.; Pal, Ayan; Horhota, Allen; Greco, Nicholas; Christianson, Carl V.; McLaughlin, Larry W.
Nucleosides, Nucleotides and Nucleic Acids, 2012 , vol. 31, # 9 p. 661 - 679
反应条件
sodium chloride in isopropyl alcohol T=0°C; Substitution; 0.166667 h; UV-irradiation;
参考文献
Kawai, Kiyohiko; Saito, Isao; Sugiyama, Hiroshi
Tetrahedron Letters, 1999 , vol. 40, # 31 p. 5721 - 5724
反应条件
thymidine phosphorylase from Escherichia coli in phosphate buffer T=35°C; pH=7.0; 2 h; Title compound not separated from byproducts;
参考文献
Hatano, Akihiko; Harano, Aiko; Kirihara, Masayuki
Chemistry Letters, 2006 , vol. 35, # 2 p. 232 - 233
反应条件
phosphate buffer; thymidine phosphorylase from Escherichia coli T=37°C; pH=7; Enzyme kinetics; Further Variations:concentration of reagent;
参考文献
Hale, JodiAnne T.; Bigelow, James C.; Mathews, Linda A.; McCormack, John J.
Biochemical Pharmacology, 2002 , vol. 64, # 10 p. 1493 - 1502
