1: 2,4-dichloro benzoic acid With sec.-butyllithium in tetrahydrofuran; cyclohexane
T=-78°C; 1 h;
2: methyl iodide in tetrahydrofuran; cyclohexane
T=-78 - 25°C; 4 h;
3: With hydrogenchloride; water
more than 3 stages;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/89897 A1, 2004 ;
Location in patent: Page 19; 20; 26 ;
WO 2004/089897 A1