5,8-二氢异喹啉-5,8-二酮合成路线 （共 24 条）
反应条件
1: benzene / 24 h / Heating 2: 68 percent / Ag2O / 1,2-dimethoxy-ethane / 6 h / Ambient temperature 3: 80 percent / 0.17 h / 150 - 160 °C View Scheme
参考文献
Potts, Kevin T.; Bhattacharjee, Debkumar; Walsh, Eileen B.
Journal of Organic Chemistry, 1986 , vol. 51, # 11 p. 2011 - 2021
反应条件
1: Diels-Alder reaction; 2: With silver(l) oxide 3: Heating;
参考文献
Koyama, Junko; Morita, Izumi; Kobayashi, Norihiro; Osakai, Toshiyuki; Usuki, Yoshinosuke; Taniguchi, Makoto
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1079 - 1082
反应条件
in benzene 48 h; Heating;
参考文献
Potts, Kevin T.; Bhattacharjee, Debkumar; Walsh, Eileen B.
Journal of Organic Chemistry, 1986 , vol. 51, # 11 p. 2011 - 2021
反应条件
pyridine; oxygen 1.) CH2Cl2, 20 deg C, 5 d; 2.) nitrobenzene, reflux, 5 h; Yield given. Multistep reaction;
参考文献
Ohgaki, Eriko; Motoyoshiya, Jiro; Narita, Susumu; Kakurai, Toshio; Hayashi, Sadao; Hirakawa, Kiyo-ichi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 11 p. 3109 - 3112
反应条件
pyridine; oxygen 1.) CH2Cl2, 20 deg C, 5 d; 2.) nitrobenzene, reflux, 5 h; Yield given. Multistep reaction;
参考文献
Ohgaki, Eriko; Motoyoshiya, Jiro; Narita, Susumu; Kakurai, Toshio; Hayashi, Sadao; Hirakawa, Kiyo-ichi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 11 p. 3109 - 3112
反应条件
sodium azide; acetic acid in tetrahydrofuran T=40°C; 2 h;
参考文献
Shanab, Karem; Schirmer, Eva; Knafl, Heike; Wulz, Eva; Holzer, Wolfgang; Spreitzer, Helmut; Schmidt, Peter; Aicher, Babette; Mueller, Gilbert; Guenther, Eckhard
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 13 p. 3950 - 3952
反应条件
bis-[(trifluoroacetoxy)iodo]benzene in water; acetonitrile
T=0°C;
参考文献
Dohi, Toshifumi; Nakae, Tomofumi; Takenaga, Naoko; Uchiyama, Teruyoshi; Fukushima, Kei-Ichiro; Fujioka, Hiromichi; Kita, Yasuyuki
Synthesis, 2012 , vol. 44, # 8 p. 1183 - 1189
反应条件
chromium(VI) oxide in acetic acid
T=40°C; 0.5 h;
参考文献
Ryu, Chung-Kyu; Lee, In-Kyung; Jung, Sung-Hee; Kang, Hye-Young; Lee, Chong-Ock
Medicinal Chemistry Research, 2000 , vol. 10, # 1 p. 40 - 49
反应条件
pyridine-2,6-dicarboxylate N-oxide; ammonium cerium(IV) nitrate in water; acetonitrile
T=0 - 5°C; 3 h; other reagent; other substrates; Product distribution;
参考文献
Kitahara; Nakai; Nakahara; Akazawa; Shimizu; Kubo
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2256 - 2263
反应条件
1: 87 percent / hydroxylamine hydrochloride; NaOH / aq. ethanol; methanol / 1.5 h / 50 - 60 °C
2: 95 percent / H2 / Pd-C / aq. ethanol / 2 h / 1551.44 Torr
3: 69 percent / CrO3 / acetic acid / 0.5 h / 40 °C
View Scheme
参考文献
Ryu, Chung-Kyu; Lee, In-Kyung; Jung, Sung-Hee; Kang, Hye-Young; Lee, Chong-Ock
Medicinal Chemistry Research, 2000 , vol. 10, # 1 p. 40 - 49
