反应条件
1.1: sulfuric acid; nitric acid / 1 h / Heating 2.1: N,N-dimethyl-aniline / Inert atmosphere 3.1: trichlorophosphate / 1,2-dichloro-ethane / 90 °C 4.1: N,N-dimethyl-formamide / 4 h / Reflux 5.1: hydrazine hydrate / tetrahydrofuran / 24 h / 20 °C 5.2: 0.5 h / pH 3 6.1: 24 h / Reflux View Scheme
参考文献
Dunstan, Mark S.; Barnes, John; Humphries, Matthew; Whitehead, Roger C.; Bryce, Richard A.; Leys, David; Stratford, Ian J.; Nolan, Karen A.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6597 - 6611
