反应条件
1.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C
3.1: water; lithium hydroxide hydrate / tetrahydrofuran / 6 h / 65 °C
3.2: pH 2
View Scheme
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; HADIDA-RUAH, Sara, Sabina; BINCH, Hayley, Marie; DENINNO, Michael, Paul; FANNING, Lev, Tyler Dewey; FRIEMAN, Bryan, A.; GROOTENHUIS, Peter, Diederik Jan; HILGRAF, Nicole; JOSHI, Pramod; KALLEL, Edward, Adam; PONTILLO, Joseph; SILINA, Alina; SHETH, Urvi, Jagdishbhai; HURLEY, Dennis, James; ARUMUGAM, Vijayalaksmi; MILLER, Mark, Thomas
Patent: WO2012/125613 A1, 2012 ;
WO 2012/125613 A1
