4-羟基吡啶-2,6-二甲酸合成路线 （共 47 条）
反应条件
phosphorus pentachloride in chlorobenzene 14 h; Heating;
参考文献
Cornejo, Alfonso; Fraile, Jose M.; Garcia, Jose I.; Gil, Maria J.; Luis, Santiago V.; Martinez-Merino, Victor; Mayoral, Jose A.
Journal of Organic Chemistry, 2005 , vol. 70, # 14 p. 5536 - 5544
参考文献
Robison
Journal of the American Chemical Society, 1958 , vol. 80, p. 5481
反应条件
1: chelidamic acid With N-(chloromethylene)-N-methylmethanaminium chloride; triethylamine; N,N-dimethyl-formamide in acetonitrile T=75°C; P=5171.62 Torr; 2: methanol in acetonitrile
参考文献
Battilocchio, Claudio; Baumann, Marcus; Baxendale, Ian R.; Biava, Mariangela; Kitching, Matthew O.; Ley, Steven V.; Martin, Rainer E.; Ohnmacht, Stephan A.; Tappin, Nicholas D. C.
Synthesis, 2012 , vol. 44, # 4 p. 635 - 647
反应条件
1: chelidamic acid With thionyl chloride Reflux; 2: methanol T=0 - 20°C; 2 h;
参考文献
Mueller, Sebastian; Sanders, Deborah A.; Di Antonio, Marco; Matsis, Stephanos; Riou, Jean-Francois; Rodriguez, Raphael; Balasubramanian, Shankar
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 32 p. 6537 - 6546
反应条件
1: phosphorus pentachloride / CCl4 / 4 h / Heating 2: 52.6 g / CCl4 / 1 h / Heating View Scheme
参考文献
Iglesias, Carlos Platas; Elhabiri, Mourad; Hollenstein, Marcel; Buenzli, Jean-Claude G.; Piguet, Claude
Journal of the Chemical Society, Dalton Transactions, 2000 , # 13 p. 2031 - 2043
反应条件
sulfuric acid T=99.84°C; 2 h; Reflux;
参考文献
Tutughamiarso, Maya; Pisternick, Thorsten; Egert, Ernst
Acta Crystallographica Section C: Crystal Structure Communications, 2012 , vol. 68, # 9 p. o344-o350
反应条件
methanol; sulfuric acid
参考文献
Guo, Xianmin; Canet, Jean-Louis; Boyer, Damien; Gautier, Arnaud; Mahiou, Rachid
Journal of Materials Chemistry, 2012 , vol. 22, # 13 p. 6117 - 6122
反应条件
1: 55 percent / PBr5 / chlorobenzene / 14 h / Heating 2: 90 percent / oxalyl chloride / CH2Cl2 / 7 h / 20 °C View Scheme
参考文献
Cornejo, Alfonso; Fraile, Jose M.; Garcia, Jose I.; Garcia-Verdugo, Eduardo; Gil, Maria J.; Legarreta, Gorka; Luis, Santiago V.; Martinez-Merino, Victor; Mayoral, Jose A.
Organic Letters, 2002 , vol. 4, # 22 p. 3927 - 3930
反应条件
1: chelidamic acid With N-(chloromethylene)-N-methylmethanaminium chloride; triethylamine; N,N-dimethyl-formamide in acetonitrile T=75°C; P=5171.62 Torr; 2: methanol in acetonitrile
参考文献
Battilocchio, Claudio; Baumann, Marcus; Baxendale, Ian R.; Biava, Mariangela; Kitching, Matthew O.; Ley, Steven V.; Martin, Rainer E.; Ohnmacht, Stephan A.; Tappin, Nicholas D. C.
Synthesis, 2012 , vol. 44, # 4 p. 635 - 647
反应条件
1: phenylphosphonic dichloride / 2 h / 120 °C 2: 1 h 3: 98 percent / aq. NaOH / 1 h / Heating 4: 61 percent / conc. H2SO4 / H2O / 12 h / 20 °C View Scheme
参考文献
Iglesias, Carlos Platas; Elhabiri, Mourad; Hollenstein, Marcel; Buenzli, Jean-Claude G.; Piguet, Claude
Journal of the Chemical Society, Dalton Transactions, 2000 , # 13 p. 2031 - 2043
