2-溴-1-苯基-1-戊酮合成路线 （共 12 条）
反应条件
1: in tetrahydrofuran 2: With hydrogenchloride in diethyl ether; water
参考文献
Power, John D.; McDermott, Sean D.; Talbot, Brian; O'Brien, John E.; Kavanagh, Pierce
Rapid Communications in Mass Spectrometry, 2012 , vol. 26, # 22 p. 2601 - 2611
反应条件
1: acetonitrile; AgNO3 2: piperidine View Scheme
参考文献
Emmons; Freeman
Journal of the American Chemical Society, 1955 , vol. 77, p. 4415
参考文献
Hyde; Browning; Adams
Journal of the American Chemical Society, 1928 , vol. 50, p. 2290
反应条件
potassium fluoride in N,N-dimethyl-formamide 3 h; Heating;
参考文献
Wagner, Peter J.; Thomas, Michael J.; Puchalski, Allen E.
Journal of the American Chemical Society, 1986 , vol. 108, # 24 p. 7739 - 7744
反应条件
ethylmagnesium bromide in diethyl ether
T=-78°C; 0.0833333 h;
参考文献
Satoh, Tsuyoshi; Itoh, Norifumi; Onda, Ken-ichi; Kitoh, Yasushi; Yamakawa, Koji
Bulletin of the Chemical Society of Japan, 1992 , vol. 65, # 10 p. 2800 - 2806
反应条件
1: C11H13PolS2 With n-butyllithium in tetrahydrofuran
T=-35°C; 2 h; solid phase reaction;
2: butyraldehyde in tetrahydrofuran; Petroleum ether
T=-35°C; solid phase reaction;
3: With N-bromosuccinmide in tetrahydrofuran; water
参考文献
Bertini, Vincenzo; Lucchesini, Francesco; Pocci, Marco; Alfei, Silvana; Idini, Barbara
Synlett, 2008 , # 8 p. 1141 - 1144
反应条件
1: oxalyl chloride, dimethyl sulfoxide / CH2Cl2 / 0.25 h / -60 °C
2: 56 percent / EtMgBr / diethyl ether / 0.08 h / -78 °C
View Scheme
参考文献
Satoh, Tsuyoshi; Itoh, Norifumi; Onda, Ken-ichi; Kitoh, Yasushi; Yamakawa, Koji
Bulletin of the Chemical Society of Japan, 1992 , vol. 65, # 10 p. 2800 - 2806
反应条件
1: 1.) LDA / 1.) THF, -78 deg C, 10 min, 2.) THF, -78 deg C, 5 min
2: oxalyl chloride, dimethyl sulfoxide / CH2Cl2 / 0.25 h / -60 °C
3: 56 percent / EtMgBr / diethyl ether / 0.08 h / -78 °C
View Scheme
参考文献
Satoh, Tsuyoshi; Itoh, Norifumi; Onda, Ken-ichi; Kitoh, Yasushi; Yamakawa, Koji
Bulletin of the Chemical Society of Japan, 1992 , vol. 65, # 10 p. 2800 - 2806
参考文献
Hyde; Browning; Adams
Journal of the American Chemical Society, 1928 , vol. 50, p. 2290
反应条件
N,N-dimethyl-formamide
参考文献
Gompper
Chemische Berichte, 1956 , vol. 89, p. 1762,1767
