4-羟基-3-甲氧基苄醇合成路线 （共 134 条）
反应条件
1.1: 27.3 g / p-TSA / methanol / 6 h / 20 °C
2.1: n-BuLi / tetrahydrofuran / 4.25 h / -15 - 0 °C
2.2: tetrahydrofuran; CH2Cl2 / -10 °C
3.1: 14.5 g / DDQ / CH2Cl2; H2O / 2 h / 20 °C
4.1: 72 percent / Br2; NaOAc; acetic acid / 8 h / 20 °C
5.1: HClO2; NaH2PO4; DMS / tetrahydrofuran; H2O / 2 h / 20 °C
6.1: 173.3 g / tetrahydrofuran; methanol
View Scheme
参考文献
Cook, Silas P.; Danishefsky, Samuel J.
Organic Letters, 2006 , vol. 8, # 25 p. 5693 - 5695
反应条件
1.1: 27.3 g / p-TSA / methanol / 6 h / 20 °C
2.1: n-BuLi / tetrahydrofuran / 4.25 h / -15 - 0 °C
2.2: tetrahydrofuran; CH2Cl2 / -10 °C
3.1: 14.5 g / DDQ / CH2Cl2; H2O / 2 h / 20 °C
4.1: 72 percent / Br2; NaOAc; acetic acid / 8 h / 20 °C
5.1: 66 percent / K2CO3 / acetone / 5 h / Heating
View Scheme
参考文献
Cook, Silas P.; Danishefsky, Samuel J.
Organic Letters, 2006 , vol. 8, # 25 p. 5693 - 5695
反应条件
sodium hydroxide in ethanol
5 h; Heating;
参考文献
Canceill, Josette; Lacombe, Liliane; Collet, Andre
Journal of the American Chemical Society, 1985 , vol. 107, # 24 p. 6993 - 6996
反应条件
sodium hydroxide in ethanol
3 h; Heating;
参考文献
Canceill, Josette; Collet, Andre
Journal of the Chemical Society, Chemical Communications, 1988 , p. 582 - 584
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=55°C;
参考文献
Wei, Qian; Seward, Garry K.; Hill, P. Aru; Patton, Brian; Dimitrov, Ivan E.; Kuzma, Nicholas N.; Dmochowski, Ivan J.
Journal of the American Chemical Society, 2006 , vol. 128, # 40 p. 13274 - 13283
反应条件
sodium hydroxide in ethanol
5 h; Heating;
参考文献
Canceill, Josette; Lacombe, Liliane; Collet, Andre
Journal of the American Chemical Society, 1985 , vol. 107, # 24 p. 6993 - 6996
反应条件
1: potassium carbonate / acetone / 0.5 h / 20 °C
2: [Ir(μ-Cl)(cyclooctene)2]2; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; lithium chloride / 1,3,5-trimethyl-benzene; water / 20 h / 170 °C / |Schlenk technique; |Inert atmosphere
View Scheme
参考文献
Olsen, Esben P. K.; Madsen, Robert
Chemistry - A European Journal, 2012 , vol. 18, # 50 p. 16023 - 16029
反应条件
(i) HCl, CH2Cl2, (ii) K2CO3; Multistep reaction;
参考文献
Pospisek,J. et al.
Collection of Czechoslovak Chemical Communications, 1975 , vol. 40, p. 142 - 148
参考文献
Koutek,B. et al.
Collection of Czechoslovak Chemical Communications, 1976 , vol. 41, p. 2250 - 2255
反应条件
acetic anhydride in potassium hydroxide; cyclohexane
参考文献
LABORATORIO FARMACEUTICO C.T. S.r.l.
Patent: EP579129 A2, 1994 ;
