4-羟基-3-甲氧基苄醇合成路线 （共 134 条）
反应条件
1: aqueous NaOH
2: aqueous NaOH
View Scheme
参考文献
Pearl
Journal of the American Chemical Society, 1946 , vol. 68, p. 429
反应条件
1: 60 percent / dimethylformamide / 20 h / 130 °C
2: 82 percent / H2; HCl / Pd/C / ethanol / 12 h / 20 °C
3: 71 percent / 2 h / Heating
View Scheme
参考文献
Jai, Woong Seo; Srisook, Ekaruth; Hyo, Jin Son; Hwang, Onyou; Cha, Young-Nam; Dae, Yoon Chi
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3369 - 3373
反应条件
1: 96 percent / K2CO3, 18-crown-6 / toluene / Heating
2: 84 percent / PBr3 / diethyl ether / 3 h / Ambient temperature
View Scheme
参考文献
Bode; Doyle; Protopopova; Zhou
Journal of Organic Chemistry, 1996 , vol. 61, # 26 p. 9146 - 9155
反应条件
1: 12.7 g / overnight
2: 2 g / sodium ethoxide / toluene / 1) 40 deg C, 0.5 h 2) room temperature, 1.5 h
View Scheme
参考文献
Shevchenko, S. M.; Yakobsons, Yu. K.; Gindin, V. A.; Gravitis, Ya. A.
Journal of Organic Chemistry USSR (English Translation), 1986 , p. 158 - 166
Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 1 p. 179 - 188
反应条件
1: 26 percent / aq. 12 N sodium hydroxide / ethanol / 5 h / Heating
2: 23 percent / sodium iodide / acetone / 8 h / Heating
View Scheme
参考文献
Canceill, Josette; Lacombe, Liliane; Collet, Andre
Journal of the American Chemical Society, 1985 , vol. 107, # 24 p. 6993 - 6996
反应条件
sulfonic acid-functionalized mesoporous silica catalyst
T=50°C; P=3000.3 Torr; 0.25 h; Product distribution; Further Variations:Catalysts;
参考文献
Morales, Gabriel; Athens, George; Chmelka, Bradley F.; van Grieken, Rafael; Melero, Juan A.
Journal of Catalysis, 2008 , vol. 254, # 2 p. 205 - 217
反应条件
potassium carbonate in acetone
T=60°C;
参考文献
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Patent: WO2008/27162 A2, 2008 ;
Location in patent: Page/Page column 24 ;
反应条件
/BRN= 506166/ in water
T=44.8 - 80.6°C; Kinetics;
参考文献
Lindgren,B.O.
Acta Chemica Scandinavica (1947-1973), 1963 , vol. 17, p. 2199 - 2202
参考文献
Lindgren,B.O.
Acta Chemica Scandinavica (1947-1973), 1963 , vol. 17, p. 2199 - 2202
反应条件
1.1: 27.3 g / p-TSA / methanol / 6 h / 20 °C
2.1: n-BuLi / tetrahydrofuran / 4.25 h / -15 - 0 °C
2.2: tetrahydrofuran; CH2Cl2 / -10 °C
3.1: 14.5 g / DDQ / CH2Cl2; H2O / 2 h / 20 °C
4.1: 72 percent / Br2; NaOAc; acetic acid / 8 h / 20 °C
5.1: 66 percent / K2CO3 / acetone / 5 h / Heating
6.1: 96 percent / p-TSA; m-CPBA / CH2Cl2 / 4 h / 0 - 20 °C
7.1: 94 percent / triethylamine / CH2Cl2; methanol / 1 h / 20 °C
View Scheme
参考文献
Cook, Silas P.; Danishefsky, Samuel J.
Organic Letters, 2006 , vol. 8, # 25 p. 5693 - 5695
