5-溴-2-羟基-3-(三氟甲氧基)苯甲醛合成路线 （共 3 条）
反应条件
N-bromosuccinmide in dichloromethane
T=20°C; 0.5 h;
参考文献
Kobashi, Seiichi; Uda, Junichiro; Miyata, Sachiho; Inoue, Tsutomu; Ashizawa, Naoki; Matsumoto, Koji; Taniguchi, Tetsuya; Iwanaga, Takashi; Nagata, Osamu
Patent: US2012/184587 A1, 2012 ;
Location in patent: Page/Page column 34 ;
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C
2.1: n-butyllithium / cyclohexane; tetrahydrofuran / 1.25 h / -60 °C / Inert atmosphere
2.2: 0.5 h / 20 °C
3.1: hydrogenchloride; water / cyclohexane; tetrahydrofuran / 15 h / 60 °C
4.1: N-bromosuccinmide / dichloromethane / 0.5 h / 20 °C
View Scheme
参考文献
Kobashi, Seiichi; Uda, Junichiro; Miyata, Sachiho; Inoue, Tsutomu; Ashizawa, Naoki; Matsumoto, Koji; Taniguchi, Tetsuya; Iwanaga, Takashi; Nagata, Osamu
Patent: US2012/184587 A1, 2012 ;
反应条件
1.1: n-butyllithium / cyclohexane; tetrahydrofuran / 1.25 h / -60 °C / Inert atmosphere
1.2: 0.5 h / 20 °C
2.1: hydrogenchloride; water / cyclohexane; tetrahydrofuran / 15 h / 60 °C
3.1: N-bromosuccinmide / dichloromethane / 0.5 h / 20 °C
View Scheme
参考文献
Kobashi, Seiichi; Uda, Junichiro; Miyata, Sachiho; Inoue, Tsutomu; Ashizawa, Naoki; Matsumoto, Koji; Taniguchi, Tetsuya; Iwanaga, Takashi; Nagata, Osamu
Patent: US2012/184587 A1, 2012 ;
