1-甲基-5-(三氟甲基)-1H-吡唑-4-羧醛合成路线 （共 3 条）
反应条件
Dess-Martin periodane in dichloromethane T=0 - 20°C;
参考文献
PFIZER JAPAN INC.; PFIZER INC.; RENOVIS, INC.
Patent: WO2008/59370 A2, 2008 ;
Location in patent: Page/Page column 53 ;
WO 2008/059370 A2
反应条件
1: 4-bromo-1-methyl-5-(trifluoromethyl)pyrazole With tert.-butyl lithium in diethyl ether; pentane T=-75°C; 0.0833333 h; 2: N,N-dimethyl-formamide Further stages.;
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
1: 67 percent / bromine; iron powder / 1 h / 100 °C 2: 67 percent / tert-butyllithium / pentane; diethyl ether / 0.08 h / -75 °C View Scheme
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
