4,5-二溴-1,2-苯二胺合成路线 （共 14 条）
反应条件
hydrogen; nickel in ethanol Reduction; P=2585.74 Torr; 0.75 h;
参考文献
Rangarajan, Meera; Kim, Jung Sun; Sim, Sai-Peng; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J.
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 11 p. 2591 - 2600
反应条件
sulfuric acid T=110°C; 0.25 h;
参考文献
Shao, Jinjun; Chang, Jingjing; Chi, Chunyan
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 35 p. 7045 - 7052
反应条件
hydrogenchloride; tin in ethanol
参考文献
Moerkved, Eva H.; Neset, Siren M.; Bjoerlo, Olav; Kjoesen, Helge; Hvistendahl, Georg; Mo, Frode
Acta Chemica Scandinavica, 1995 , vol. 49, # 9 p. 658 - 662
反应条件
aq NaOH in ethyl acetate
参考文献
Eli Lilly and Company
Patent: US4264600 A1, 1981 ;
反应条件
1: 80 percent / Br2 in AcOH, NaOAc 2: 90 percent / sulphuric acid View Scheme
参考文献
Wasik, Romualda; Winska, Patrycja; Poznanski, Jaroslaw; Shugar, David
Journal of Physical Chemistry B, 2012 , vol. 116, # 24 p. 7259 - 7268
反应条件
1: 87 percent / pyridine 2: 89 percent / Br2, acetic acid, sodium acetate 3: 83.5 percent / sulfuric acid View Scheme
参考文献
Yilmaz, Ismail; Bekaroglu, Oezer
Journal of Chemical Research, Miniprint, 1998 , # 7 p. 1585 - 1594
反应条件
1: dioxane / 20 h / Ambient temperature 2: concd. H2SO4, concd. HNO3 / 4 h / 0 °C 3: 7percent aq. K2CO3 / methanol / 4 h / Ambient temperature 4: H2 / 10percent Pd/C / methanol / 3 h / 1034.3 - 1551.4 Torr View Scheme
参考文献
Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379
反应条件
1: concd. H2SO4, concd. HNO3 / 4 h / 0 °C 2: 7percent aq. K2CO3 / methanol / 4 h / Ambient temperature 3: H2 / 10percent Pd/C / methanol / 3 h / 1034.3 - 1551.4 Torr View Scheme
参考文献
Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379
反应条件
1: 35 percent / HNO3, H2SO4 / 10 h / Heating 2: 100 percent / Sn, HCl / ethanol View Scheme
参考文献
Moerkved, Eva H.; Neset, Siren M.; Bjoerlo, Olav; Kjoesen, Helge; Hvistendahl, Georg; Mo, Frode
Acta Chemica Scandinavica, 1995 , vol. 49, # 9 p. 658 - 662
反应条件
hydrogenchloride; tin
参考文献
Woolley; Pringle
Journal of Biological Chemistry, 1952 , vol. 194, p. 729,734
