N-(叔-丁氧羰基)-L-谷氨酰胺甲酯合成路线 （共 9 条）
反应条件
bromine; sodium methylate Substitution; 0.5 h; Heating;
参考文献
Matsumura, Yoshihiro; Yuki Satoh, Kimihiro Shirai; Onomura, Osamu; Toshihide, Maki
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 15 p. 2057 - 2060
反应条件
in methanol; ethyl acetate
1.) 0 deg C, 5 min, 2.) RT, 20 min;
参考文献
Castonguay, Roselyne; Lherbet, Christian; Keillor, Jeffrey W.
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 12 p. 4185 - 4191
反应条件
ammonium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide in tetrahydrofuran
15 h; Ambient temperature;
参考文献
Dzierzbicka, Krystyna; Kolodziejczyk, Aleksander M.
Polish Journal of Chemistry, 1991 , vol. 65, # 7-8 p. 1437 - 1439
反应条件
in methanol; hexane; toluene
0.5 h; Inert atmosphere;
参考文献
Berkheij, Martin; Dijkink, Jan; David, Olivier R. P.; Sonke, Theo; Ijzendoorn, Denis R.; Blaauw, Richard H.; Van Maarseveen, Jan H.; Schoemaker, Hans E.; Hiemstra, Henk
European Journal of Organic Chemistry, 2008 , # 5 p. 914 - 924
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; Methylation; 6 h;
参考文献
Matsumura, Yoshihiro; Yuki Satoh, Kimihiro Shirai; Onomura, Osamu; Toshihide, Maki
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 15 p. 2057 - 2060
反应条件
trans-N,N'-bis-[pyridin-2-ylmethylene]-cyclohexane-1,2-diamine; sodium methylate; ytterbium(III) triflate in acetonitrile
T=25°C; pH=6.5; Kinetics; Reagent/catalystpH-valueTemperature; optical yield given as percent ee;
参考文献
Maxwell, Christopher I.; Shah, Kalpa; Samuleev, Pavel V.; Neverov, Alexei A.; Brown, R. Stan
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 15 p. 2796 - 2803
反应条件
1: NaOH; H2O / tetrahydrofuran / 5 h / 20 °C
2: K2CO3 / dimethylformamide / 6 h / 20 °C
View Scheme
参考文献
Matsumura, Yoshihiro; Yuki Satoh, Kimihiro Shirai; Onomura, Osamu; Toshihide, Maki
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 15 p. 2057 - 2060
反应条件
1: NaOH; H2O / tetrahydrofuran / 5 h / 20 °C
2: K2CO3 / dimethylformamide / 6 h / 20 °C
View Scheme
参考文献
Matsumura, Yoshihiro; Yuki Satoh, Kimihiro Shirai; Onomura, Osamu; Toshihide, Maki
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 15 p. 2057 - 2060
反应条件
trans-N,N'-bis-[pyridin-2-ylmethylene]-cyclohexane-1,2-diamine; sodium methylate; ytterbium(III) triflate in acetonitrile
T=25°C; pH=6.5; Kinetics; Reagent/catalystpH-valueTemperature;
参考文献
Maxwell, Christopher I.; Shah, Kalpa; Samuleev, Pavel V.; Neverov, Alexei A.; Brown, R. Stan
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 15 p. 2796 - 2803
