苄氧羰基-丙氨酰-甘氨酰胺合成路线 （共 8 条）
反应条件
triethylamine; enzyme mutant SBL-S166C-S-(CH2)2-NMe3(1+) in water; N,N-dimethyl-formamide
T=20°C; pH=5.8; 5 h;
参考文献
Matsumoto, Kazutsugu; Davis, Benjamin G.; Jones, J. Bryan
Chemistry - A European Journal, 2002 , vol. 8, # 18 p. 4129 - 4137
反应条件
1: N-carbobenzoxy-L-alanine With 1,1'-carbonyldiimidazole in tetrahydrofuran
T=20°C; Acylation; 2 h;
2: 2-amino-acetamide hydrochloride With triethylamine in tetrahydrofuran
T=20°C; Acylation; Further stages.;
参考文献
Sutton; Clardy
Organic letters, 2000 , vol. 2, # 3 p. 319 - 321
反应条件
α-chymotrypsin immobilised on Celite; triethylamine in acetonitrile
T=30°C; pH=7.8; 48 h;
参考文献
Miyazawa, Toshifumi; Ensatsu, Eiichi; Yabuuchi, Nobuhiro; Yanagihara, Ryoji; Yamada, Takashi
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 3 p. 390 - 395
反应条件
1: 10.9 percent / Et3N; α-chymotrypsin immobilised on Celite / acetonitrile; various solvent(s) / 48 h / 30 °C / pH 7.8
2: Et3N; EDC; HOBT / dimethylformamide
View Scheme
参考文献
Miyazawa, Toshifumi; Ensatsu, Eiichi; Yabuuchi, Nobuhiro; Yanagihara, Ryoji; Yamada, Takashi
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 3 p. 390 - 395
反应条件
1: 8.6 percent Chromat. / Et3N; α-chymotrypsin immobilised on Celite / acetonitrile; various solvent(s) / 48 h / 30 °C / pH 7.8
2: Et3N; EDC; HOBT / dimethylformamide
View Scheme
参考文献
Miyazawa, Toshifumi; Ensatsu, Eiichi; Yabuuchi, Nobuhiro; Yanagihara, Ryoji; Yamada, Takashi
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 3 p. 390 - 395
反应条件
α-chymotrypsin immobilised on Celite; triethylamine in acetonitrile
T=30°C; pH=7.8; 48 h;
参考文献
Miyazawa, Toshifumi; Ensatsu, Eiichi; Yabuuchi, Nobuhiro; Yanagihara, Ryoji; Yamada, Takashi
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 3 p. 390 - 395
反应条件
α-chymotrypsin immobilised on Celite; triethylamine in acetonitrile
T=30°C; pH=7.8; 48 h;
参考文献
Miyazawa, Toshifumi; Ensatsu, Eiichi; Yabuuchi, Nobuhiro; Yanagihara, Ryoji; Yamada, Takashi
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 3 p. 390 - 395
反应条件
proteinase K in water; isopropyl alcohol
T=30°C; 8 h; other time; Product distribution;
参考文献
Cerovsky, Vaclav; Martinek, Karel
Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 7 p. 2027 - 2041
