8-溴-2,3,4,5-四氢-1H-吡啶并[4,3-b]吲哚合成路线 （共 3 条）
反应条件
1: in ethanol 4 h; Heating / reflux; 2: With hydrogenchloride in ethanol T=20°C; 3 h; Heating / reflux; 3: With sodium hydroxide in water pH=12;
参考文献
MIKANA THERAPEUTICS, INC.
Patent: WO2006/88949 A1, 2006 ;
Location in patent: Page/Page column 113; 114 ;
反应条件
hydrogenchloride in ethanol 3 h; Reflux;
参考文献
Ye, Lianbao; Tian, Yuanxin; Li, Zhonghuang; Zhang, Jiajie; Wu, Shuguang
Helvetica Chimica Acta, 2012 , vol. 95, # 2 p. 320 - 326
反应条件
1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C 1.2: 3 h / 0 - 20 °C 2.1: ethanol / 3 h / |Reflux View Scheme
参考文献
Ferguson, Fleur M.; Fedorov, Oleg; Chaikuad, Apirat; Philpott, Martin; Muniz, Joao R. C.; Felletar, Ildiko; Von Delft, Frank; Heightman, Tom; Knapp, Stefan; Abell, Chris; Ciulli, Alessio
Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 10183 - 10187
