1: di-tert-butyl phosphite With potassium permanganate; potassium hydrogencarbonate in water T=0 - 20°C; 2: chloromethyl chlorosulphate With tetra(n-butyl)ammonium hydrogensulfate; potassium hydrogencarbonate in dichloromethane; water T=5 - 20°C; 71 h;
1: 4-methoxy-benzoic acid With sodium hydrogencarbonate; tetra(n-butyl)ammonium hydrogensulfate in dichloromethane; water
T=0°C; 0.0833333 h;
2: chloromethyl chlorosulphate in dichloromethane; water
参考文献
SEMAFORE PHARMACEUTICALS, INC.; GARLICH, Joseph, R.; DURDEN, Donald, L.
Patent: WO2004/89925 A1, 2004 ;
Location in patent: Page 43 ;
WO 2004/089925 A1
tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate in dichloromethane; water
T=20°C; 4 h; Inert atmosphere;
参考文献
Hedge, Matthew K.; Gehring, Alexandra M.; Adkins, Chinessa T.; Weston, Leigh A.; Lavis, Luke D.; Johnson, R. Jeremy
Biochimica et Biophysica Acta - Proteins and Proteomics, 2012 , vol. 1824, # 9 p. 1024 - 1030
tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate in dichloromethane; water
T=20°C; 4 h; Inert atmosphere;
参考文献
Hedge, Matthew K.; Gehring, Alexandra M.; Adkins, Chinessa T.; Weston, Leigh A.; Lavis, Luke D.; Johnson, R. Jeremy
Biochimica et Biophysica Acta - Proteins and Proteomics, 2012 , vol. 1824, # 9 p. 1024 - 1030
