1-甲基吡咯-2-乙酸乙酯合成路线 （共 11 条）
反应条件
hydrazine hydrate in ethanol
参考文献
Pitucha, Monika; Rzymowska, Jolanta; Olender, Alina; Grzybowska-Szatkowska, Ludmia
Journal of the Serbian Chemical Society, 2012 , vol. 77, # 1 p. 1 - 8
参考文献
Rapoport; Jorgensen
Journal of Organic Chemistry, 1949 , vol. 14, p. 664,667
反应条件
zinc in acetic acid
T=100 - 110°C; 1 h;
参考文献
Tamura, Yasumitsu; Choi, Hong Dae; Shindo, Hirohisa; Ishibashi, Hiroyuki
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 3 p. 915 - 921
反应条件
sulfuric acid; silica gel in dichloromethane
T=0°C; Decarboxylation; cyclodehydration; 1 h;
参考文献
Kawano, Tomikazu; Negoro, Kenji; Nitta, Hajime; Ueda, Ikuo
Heterocycles, 2000 , vol. 52, # 3 p. 1261 - 1278
反应条件
sulfuric acid; silica gel in dichloromethane
T=0°C; acidolysis; 0.333333 h;
参考文献
Kawano, Tomikazu; Negoro, Kenji; Nitta, Hajime; Ueda, Ikuo
Heterocycles, 2000 , vol. 52, # 3 p. 1261 - 1278
参考文献
Sohl; Shriner
Journal of the American Chemical Society, 1933 , vol. 55, p. 3828,3831
Full Text Show Details
Rapoport; Jorgensen
Journal of Organic Chemistry, 1949 , vol. 14, p. 664,667
Full Text Show Details
Nenitzescu; Solomonica
Chemische Berichte, 1931 , vol. 64, p. 1924,1930
反应条件
1: 52 percent / tetrahydrofuran / 24 h / 20 °C
2: 82 percent / NaH in mineral oil / dimethylformamide / 1.5 h / 0 °C
3: 26 percent / 97 percent concd. sulfuric acid; silica gel / CH2Cl2 / 1 h / 0 °C
View Scheme
参考文献
Kawano, Tomikazu; Negoro, Kenji; Nitta, Hajime; Ueda, Ikuo
Heterocycles, 2000 , vol. 52, # 3 p. 1261 - 1278
反应条件
1: 82 percent / NaH in mineral oil / dimethylformamide / 1.5 h / 0 °C
2: 26 percent / 97 percent concd. sulfuric acid; silica gel / CH2Cl2 / 1 h / 0 °C
View Scheme
参考文献
Kawano, Tomikazu; Negoro, Kenji; Nitta, Hajime; Ueda, Ikuo
Heterocycles, 2000 , vol. 52, # 3 p. 1261 - 1278
反应条件
thionyl chloride
Behandeln des Reaktionsprodukts mit Diazomethan in Dioxan und anschliessendem Erhitzen mit Aethanol in Gegenwart von etwas Platin auf 180grad;
参考文献
Arndt; Eistert
Patent: DE650706 , 1933 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 23, p. 582
参考文献
Nenitzescu; Solomonica
Chemische Berichte, 1931 , vol. 64, p. 1924,1930
