2,2'-联吡啶-6,6'-二甲醛合成路线 （共 11 条）
反应条件
selenium(IV) oxide in acetic acid
24 h; Heating;
参考文献
Newkome,G.R.; Leg,H.W.
Journal of the American Chemical Society, 1983 , vol. 105, p. 5956
反应条件
1: 6,6'-dibromo-2,2'-dipyridyl With n-butyllithium in tetrahydrofuran
T=-90°C; 0.75 h;
2: N,N-dimethyl-formamide in tetrahydrofuran
T=-80 - -30°C; Further stages.;
参考文献
Ilyashenko, Gennadiy; Choudhury, Rahela; Motevalli, Majid; Watkinson, Michael
Synlett, 2006 , # 11 p. 1759 - 1761
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane
T=-60°C; Swern Oxidation; 0.25 h; Inert atmosphere;
2: With triethylamine in dichloromethane
T=20°C; Swern Oxidation; 5 h; CoolingInert atmosphere;
参考文献
Alzakhem, Nicola; Bischof, Caroline; Seitz, Michael
Inorganic Chemistry, 2012 , vol. 51, # 17 p. 9343 - 9349
参考文献
Davies, Stephen R.; Mitchell, Michael C.; Cain, Christopher P.; Devitt, Paul G.; Taylor, Roger J.; Kee, Terence P.
Journal of Organometallic Chemistry, 1998 , vol. 550, # 1-2 p. 29 - 57
反应条件
1: 30 percent / NiCl2(PPh3)2, Zn, NEt4I / tetrahydrofuran
2: 77 percent / aq. HCl
View Scheme
参考文献
Davies, Stephen R.; Mitchell, Michael C.; Cain, Christopher P.; Devitt, Paul G.; Taylor, Roger J.; Kee, Terence P.
Journal of Organometallic Chemistry, 1998 , vol. 550, # 1-2 p. 29 - 57
反应条件
dimethyl sulfoxide
T=150°C; 8 h;
参考文献
Voegtle, Fritz; Hochberg, Robert; Kochendoerfer, Frank; Windscheif, Paul-Michael; Volkmann, Martin; Jansen, Martin
Chemische Berichte, 1990 , vol. 123, # 11 p. 2181 - 2185
反应条件
1: 54 percent / n-BuLi / diethyl ether
2: 72 percent / benzene
3: 30 percent / NiCl2(PPh3)2, Zn, NEt4I / tetrahydrofuran
4: 77 percent / aq. HCl
View Scheme
参考文献
Davies, Stephen R.; Mitchell, Michael C.; Cain, Christopher P.; Devitt, Paul G.; Taylor, Roger J.; Kee, Terence P.
Journal of Organometallic Chemistry, 1998 , vol. 550, # 1-2 p. 29 - 57
反应条件
1: 72 percent / benzene
2: 30 percent / NiCl2(PPh3)2, Zn, NEt4I / tetrahydrofuran
3: 77 percent / aq. HCl
View Scheme
参考文献
Davies, Stephen R.; Mitchell, Michael C.; Cain, Christopher P.; Devitt, Paul G.; Taylor, Roger J.; Kee, Terence P.
Journal of Organometallic Chemistry, 1998 , vol. 550, # 1-2 p. 29 - 57
反应条件
1: 1) 48percent HBr, Br2 2) NaNO2 / 1) -15 to -10 deg C, 30 min 2) water, 90 min
2: 1) Raney Nickel 2) water / 1) toluene, 22 h, reflux 2) 2 h, 40 deg C
3: 25 percent / NBS, AIBN, 62percent HBr, Br2 / CCl4 / 4 h / Heating
4: 20 percent / DMSO / 8 h / 150 °C
View Scheme
参考文献
Voegtle, Fritz; Hochberg, Robert; Kochendoerfer, Frank; Windscheif, Paul-Michael; Volkmann, Martin; Jansen, Martin
Chemische Berichte, 1990 , vol. 123, # 11 p. 2181 - 2185
反应条件
1: 1) Raney Nickel 2) water / 1) toluene, 22 h, reflux 2) 2 h, 40 deg C
2: 25 percent / NBS, AIBN, 62percent HBr, Br2 / CCl4 / 4 h / Heating
3: 20 percent / DMSO / 8 h / 150 °C
View Scheme
参考文献
Voegtle, Fritz; Hochberg, Robert; Kochendoerfer, Frank; Windscheif, Paul-Michael; Volkmann, Martin; Jansen, Martin
Chemische Berichte, 1990 , vol. 123, # 11 p. 2181 - 2185
