2-溴-6-(2-甲基-1,3-二氧戊烷-2-基)吡啶合成路线 （共 6 条）
反应条件
p-toluenesulfonic acid monohydrate in toluene 24 h; Heating;
参考文献
Ronson, Tanya K.; Adams, Harry; Harding, Lindsay P.; Pope, Simon J. A.; Sykes, Daniel; Faulkner, Stephen; Ward, Michael D.
Dalton Transactions, 2007 , # 10 p. 1006 - 1022
反应条件
1.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C 1.2: 76 percent / hexane; diethyl ether / 1 h / -78 - 20 °C 2.1: 79 percent / p-TsOH / H2O; toluene / 4 h / 140 °C View Scheme
参考文献
Poellnitz, Alpar; Skupienski, Radek; Stoeckli-Evans, Helen; Crochet, Aurelien; Silvestru, Anca; Fromm, Katharina M.; Mamula, Olimpia
Synlett, 2013 , vol. 24, # 19 art. no. ST-2013-B0678-L, p. 2555 - 2558
反应条件
1: 1.) Et2O, hexane, -40 deg C, 45 min, 2.) Et2O, hexane, rt, overnight 2: 1.66 g / HCl / aq. HCl / 3 h / 60 °C 3: 69 percent / t-BuOK / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Constable; Heirtzler; Neuburger; Zehnder
Journal of the American Chemical Society, 1997 , vol. 119, # 24 p. 5606 - 5617
反应条件
1.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C 1.2: 54 percent / hexane; diethyl ether / 1 h / -78 - 20 °C 2.1: 82 percent / hydrochloric acid / 2 h / 100 °C View Scheme
参考文献
Hatanaka, Masashi; Takahashi, Kyoko; Nakamura, Shigeo; Mashino, Tadahiko
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 24 p. 6763 - 6770
反应条件
1.1: n-butylithium / diethyl ether / 0.5 h / -60 °C 1.2: 57 percent / diethyl ether / -60 - 20 °C 2.1: 93 percent / HCl / 2 h / Heating View Scheme
参考文献
Dalton Transactions, , # 10 p. 1006 - 1022
反应条件
1: 6-bromo-2-(2'-methyl-1',3'-dioxolan-2'-yl)-pyridine With n-butyllithium in diethyl ether T=-60°C; 0.5 h; 2: carbon dioxide in diethyl ether T=-60 - 20°C;
参考文献
Dalton Transactions, , # 10 p. 1006 - 1022
