1-(4-溴苯基)-2-甲基丙烷-1-酮合成路线 （共 17 条）
反应条件
1: bromine; chlorosulfonic acid / chlorobenzene / 20 °C 2: chlorobenzene; methanol / 1.5 h / 20 °C 3: 21 h / 130 °C View Scheme
参考文献
BASF SE; FREY, Markus; ROHWER, Hauke; WENDEBORN, Frederique; HAZENKAMP, Menno
Patent: WO2012/846 A1, 2012 ;
反应条件
(i) NaNH2, toluene, (ii) /BRN= 969135/; Multistep reaction;
参考文献
Bertsch,K. et al.
Chemische Berichte, 1979 , vol. 112, p. 567 - 576
Full Text Show Details
Walton,D.R.M.
Journal of Organometallic Chemistry, 1965 , vol. 3, p. 438 - 441
反应条件
chromium(VI) oxide; sulfuric acid in water; acetone
2 h;
参考文献
MERCK PATENT GMBH
Patent: WO2004/37806 A1, 2004 ;
Location in patent: Page 38 ;
反应条件
diethylzinc; trifluoroacetic acid in dichloromethane
T=20°C; 2 h; Inert atmosphere;
参考文献
Wang, Zhihui; Li, Meiyi; Zhang, Wenqin; Jia, Jiangnan; Wang, Fei; Xue, Song
Tetrahedron Letters, 2011 , vol. 52, # 45 p. 5968 - 5971
反应条件
AlCl3, aluminium chloride in neat (no solvent)
T=20°C; Friedel-Crafts Acylation; Inert atmosphere;
参考文献
Rennison, David; Conole, Daniel; Tingle, Malcolm D.; Yang, Junpeng; Eason, Charles T.; Brimble, Margaret A.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6629 - 6635
反应条件
[2,2']bipyridinyl; palladium (II) trifluoroacetate; water; trifluoroacetic acid in tetrahydrofuran
T=80°C; 36 h; Inert atmosphereSchlenk technique;
参考文献
Wang, Xingyong; Liu, Miaochang; Xu, Long; Wang, Qingzong; Chen, Jiuxi; Ding, Jinchang; Wu, Huayue
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5273 - 5281
反应条件
[(η5-C5Me5)2Rh2(μ-Cl)2Cl2]; oxygen; caesium carbonate in methanol
T=65°C; 48 h; Sealed tube; ConcentrationTime;
参考文献
Chan, Louis K. M.; Poole, Darren L.; Shen, Di; Healy, Mark P.; Donohoe, Timothy J.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 3 p. 761 - 765
Angew. Chem., 2014 , vol. 126, # 3 p. 908
反应条件
(NMe4)Co(III)Me2opba*2H2O*CH3CN; oxygen; pivalaldehyde in acetonitrile
8.5 h;
参考文献
Blay, Gonzalo; Fernandez, Isabel; Formentin, Pilar; Monje, Belen; Pedro, Jose R; Ruiz, Rafael
Tetrahedron, 2001 , vol. 57, # 6 p. 1075 - 1081
参考文献
Shell Oil Company
Patent: US4079149 A1, 1978 ;
反应条件
n-butyllithium
1.) THF, hexane, 20 min, 2.) THF, hexane, RT, 2 h; Yield given. Multistep reaction;
参考文献
Matsumoto, Takuya; Ishida, Takayuki; Koga, Noboru; Iwamura, Hiizu
Journal of the American Chemical Society, 1992 , vol. 114, # 25 p. 9952 - 9959
