1-甲基-1,2,3,4-四氢异喹啉合成路线 （共 44 条）
反应条件
pentamethylcyclopentadienyliridium (III)Iodide Dimer T=40°C;
参考文献
Organic Process Research and Development, , vol. 11, # 3 p. 642 - 648
反应条件
1: (isoPrO)4Ti / 3 h / 80 °C 2: NaBH4 / methanol / 1 h / Ambient temperature 3: 98 percent / Ac2O / 1 h / 70 °C 4: 93 percent / NaIO4 / H2O; methanol / Ambient temperature 5: 1.) TFAA; 2.) BF3*Et2O / 1.) benzene, RT, 1 h; 2.) benzene, RT, 1 h 6: 85 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 7: 93 percent / aq. NaOH / ethanol / 5 h / Heating View Scheme
参考文献
Heterocycles, , vol. 46, # 1 p. 555 - 565
反应条件
1: 98 percent / Ac2O / 1 h / 70 °C 2: 93 percent / NaIO4 / H2O; methanol / Ambient temperature 3: 1.) TFAA; 2.) BF3*Et2O / 1.) benzene, RT, 1 h; 2.) benzene, RT, 1 h 4: 85 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 5: 93 percent / aq. NaOH / ethanol / 5 h / Heating View Scheme
参考文献
Heterocycles, , vol. 46, # 1 p. 555 - 565
反应条件
1: 85 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 2: 93 percent / aq. NaOH / ethanol / 5 h / Heating View Scheme
参考文献
Heterocycles, , vol. 46, # 1 p. 555 - 565
反应条件
1: 93 percent / NaIO4 / H2O; methanol / Ambient temperature 2: 1.) TFAA; 2.) BF3*Et2O / 1.) benzene, RT, 1 h; 2.) benzene, RT, 1 h 3: 85 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 4: 93 percent / aq. NaOH / ethanol / 5 h / Heating View Scheme
参考文献
Heterocycles, , vol. 46, # 1 p. 555 - 565
反应条件
1: 1.) TFAA; 2.) BF3*Et2O / 1.) benzene, RT, 1 h; 2.) benzene, RT, 1 h 2: 85 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 3: 93 percent / aq. NaOH / ethanol / 5 h / Heating View Scheme
参考文献
Heterocycles, , vol. 46, # 1 p. 555 - 565
反应条件
1: 1) N,N,N',N'-tetramethylethylenediamine, t-BuLi / THF, pentane 1) -78 deg C, 40 min 2) -78 deg C, 3 h 2: 99 percent / CF3COOH / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 28, # 7 p. 1769 - 1772
反应条件
C21H21ClIrNO2 in 2,2,2-trifluoroethanol 3 h; RefluxInert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 27 p. 6983 - 6987
Ross. Khim. Zh., , vol. 125, # 27 p. 7121 - 7125,5
反应条件
hydrogenchloride; zinc
参考文献
Journal of Organic Chemistry, , vol. 16, p. 1911,1913
反应条件
1.1: LDA / tetrahydrofuran / 0.5 h / -78 °C 1.2: tetrahydrofuran / -78 - 20 °C 2.1: hydrazine hydrate; glacial acetic acid / ethanol / 60 °C View Scheme
参考文献
Synthetic Communications, , vol. 36, # 22 p. 3339 - 3343
