sulfuryl dichloride

sodium periodate in methanol Ambient temperature;

nitric acid in acetonitrile T=20°C; 60 h; chemoselective reaction;

1: 67 percent / aq. KOH / ethanol / 1 h / Heating 2: DMF, SOCl2 / 1 h / Heating 3: 28percent aq. NH4OH / 1 h / 0 °C 4: 93 percent / NaIO4 / methanol / Ambient temperature View Scheme

1: DMF, SOCl2 / 1 h / Heating 2: 28percent aq. NH4OH / 1 h / 0 °C 3: 93 percent / NaIO4 / methanol / Ambient temperature View Scheme

1: 28percent aq. NH4OH / 1 h / 0 °C 2: 93 percent / NaIO4 / methanol / Ambient temperature View Scheme

1: 94 percent / Et3N / 1.) r.t., 5 min, 2.) 50 - 60 deg C, 1 h 2: 67 percent / aq. KOH / ethanol / 1 h / Heating 3: DMF, SOCl2 / 1 h / Heating 4: 28percent aq. NH4OH / 1 h / 0 °C 5: 93 percent / NaIO4 / methanol / Ambient temperature View Scheme