1,3-二氢异苯并呋喃合成路线 （共 101 条）
反应条件
2-hydroxy-1,3-isoindolinedione; nitrogen(II) oxide in acetonitrile T=60°C; other reagents, temperature; time dependence; Product distribution;
参考文献
Journal of Organic Chemistry, , vol. 64, # 13 p. 4676 - 4679
反应条件
benzophenone in water; acetonitrile T=20°C; 1 h; Irradiation; chemoselective reaction;
参考文献
Chemical Science, , vol. 4, # 8 p. 3118 - 3123
反应条件
1: With sulfuric acid; potassium nitrate T=0°C; 0.5 h; 2: With tin(ll) chloride in ethanol T=70°C; 2 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/2342 A1, 2006 ;
Location in patent: Page/Page column 136-137 ;
反应条件
dihydrogen peroxide; trifluoroacetic acid; zinc dibromide in 1,4-dioxane; water T=100°C; 16 h;
参考文献
Wu, Xiao-Feng
Tetrahedron Letters, 2012 , vol. 53, # 45 p. 6123 - 6126
参考文献
Yus, Miguel; Gomis, Joaquin
European Journal of Organic Chemistry, 2002 , # 12 p. 1989 - 1995
反应条件
1: 1,3-dihydro-isobenzofuran With n-butyllithium; 2-(dimethylamino)-ethanol in hexane T=-15°C; 0.333333 h; 2: 2-iodo-propane in tetrahydrofuran T=-78°C;
参考文献
Fort, Yves; Gros, Philippe; Rodriguez, Alain L
Tetrahedron Letters, 2002 , vol. 43, # 22 p. 4045 - 4048
反应条件
1: 1) sec-BuLi / 1) THF, -40 deg C, 2 h, 2) THF, 1 h
2: 1) Li, naphthalene, 2) H2O / 1) THF, 0 deg C, 5 h
View Scheme
参考文献
Azzena, Ugo; Demartis, Salvatore; Melloni, Giovanni
Journal of Organic Chemistry, 1996 , vol. 61, # 15 p. 4913 - 4919
反应条件
naphthalene; lithium
1) THF, 0 deg C, 1.5 h, 2) THF, 0 deg C, 60 min; Yield given. Multistep reaction;
参考文献
Azzena, Ugo; Demartis, Salvatore; Melloni, Giovanni
Journal of Organic Chemistry, 1996 , vol. 61, # 15 p. 4913 - 4919
反应条件
1: 1) Li, naphthalene / 1) THF, 0 deg C, 1.5 h, 2) THF, 0 deg C, 60 min
2: 56 percent Turnov. / KMnO4 / H2O / 24 h / Ambient temperature
View Scheme
参考文献
Azzena, Ugo; Demartis, Salvatore; Melloni, Giovanni
Journal of Organic Chemistry, 1996 , vol. 61, # 15 p. 4913 - 4919
