4-溴-2-溴甲基-1-碘苯合成路线 （共 5 条）
反应条件
PPh3.Br2 in acetonitrile T=5 - 20°C;
参考文献
Chouhan, Gagan; Alper, Howard
Journal of Organic Chemistry, 2009 , vol. 74, # 16 p. 6181 - 6189
反应条件
N-bromosuccinmide; dibenzoyl peroxide in 1,2-dichloro-ethane 5 h; Inert atmosphereRefluxIrradiation;
参考文献
THE JOHNS HOPKINS UNIVERSITY; TOVAR, John Dayton; CARUSO, Jr., Anthony
Patent: WO2011/127383 A2, 2011 ;
Location in patent: Page/Page column 74 ;
反应条件
1: BH3*SMe2 / tetrahydrofuran / 0 - 20 °C 2: CBr4; PPH3 / CH2Cl2 / 0 °C View Scheme
参考文献
Pletnev, Alexandre A.; Larock, Richard C.
Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9428 - 9438
反应条件
4-methylmorpholine N-oxide in acetonitrile T=0 - 20°C; Inert atmosphereMolecular sieve;
参考文献
THE JOHNS HOPKINS UNIVERSITY; TOVAR, John Dayton; CARUSO, Jr., Anthony
Patent: WO2011/127383 A2, 2011 ;
Location in patent: Page/Page column 75 ;
反应条件
1.1: n-BuLi; i-Pr2NH / hexane; tetrahydrofuran / 1 h / -78 °C
1.2: 48 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 3 percent / PPh3; Et3N / Pd(OAc)2 / dimethylformamide; H2O / 15 h / 130 °C
View Scheme
参考文献
Pletnev, Alexandre A.; Larock, Richard C.
Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9428 - 9438
