3-(2-羟基苯基)丙酸合成路线 （共 44 条）
反应条件
in trifluoroacetic acid
T=0 - 20°C; Inert atmosphere;
参考文献
Huhtiniemi, Tero; Salo, Heikki S.; Suuronen, Tiina; Poso, Antti; Salminen, Antero; Leppaenen, Jukka; Jarho, Elina; Lahtela-Kakkonen, Maija
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6456 - 6468
反应条件
1: 75 percent / K2CO3, KI / acetone / 12 h / Heating
2: 80 percent / 10percent aq. NaOH / methanol / 12 h
3: 1.) thionyl chloride / THF; 1.) reflux, 4 h; 2.) room temp., 12 h
4: 94 percent / hydrogen / Pd/C / ethanol / 8 h
5: acetonitrile; H2O / 50 °C / rate constants (kOH) for lactonization (buffered solution pH 10.0); other temp.: 70, 90 deg C
6: 91 percent / lithium aluminum hydride / tetrahydrofuran
View Scheme
参考文献
Amsberry, Kent L.; Borchardt, Ronald T.
Journal of Organic Chemistry, 1990 , vol. 55, # 23 p. 5867 - 5877
参考文献
Borsche; Streitberger
Chemische Berichte, 1904 , vol. 37, p. 4127
参考文献
Pschorr; Einbeck
Chemische Berichte, 1905 , vol. 38, p. 2069
