4-(2-溴苯基)哌嗪-1-羧酸叔丁酯合成路线 (共 3 条)
反应条件
2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) in toluene T=80°C; 24 h;
参考文献
Tetrahedron, , vol. 64, # 13 p. 2938 - 2950
反应条件
tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; sodium t-butanolate in toluene T=80°C; 16 h; Inert atmosphere;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 17 p. 5316 - 5322
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-70°C; 1 h;
2: With isopropyldiisopropoxyborane in tetrahydrofuran; hexane
T=-70 - 20°C; 1.16667 h;
3: With water; ammonium chloride in tetrahydrofuran; hexane; isopropyl alcohol
0.5 h;
参考文献
Eisai R and D Management Co., Ltd.
Patent: WO2006/126635 A1, 2006 ;
Location in patent: Page/Page column 44-45 ;