2-氨基-N-(2-丙炔)苯羧酰胺合成路线 （共 10 条）
反应条件
in tetrahydrofuran T=0°C; 2 h;
参考文献
Weinberg, Linda R.; Albom, Mark S.; Angeles, Thelma S.; Husten, Jean; Lisko, Joseph G.; McHugh, Robert J.; Milkiewicz, Karen L.; Murthy, Seetha; Ott, Gregory R.; Theroff, Jay P.; Tripathy, Rabindranath; Underiner, Ted L.; Zificsak, Craig A.; Dorsey, Bruce D.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 164 - 167
反应条件
Al/Hg amalgam in diethyl ether; ethanol; water T=20°C; 2 h;
参考文献
Howell, Lesley A.; Bowater, Richard A.; O'Connell, Maria A.; Reszka, Anthony P.; Neidle, Stephen; Searcey, Mark
ChemMedChem, 2012 , vol. 7, # 5 p. 792 - 804
反应条件
1: N,N-dimethyl-formamide / 10 h / 50 °C 2: sodium hydroxide / water View Scheme
参考文献
Guggenheim, Kathryn G.; Toru, Hannah; Kurth, Mark J.
Organic Letters, 2012 , vol. 14, # 14 p. 3732 - 3735
反应条件
1: triethylamine / dichloromethane / 2 h / 20 °C 2: Al/Hg amalgam / diethyl ether; ethanol; water / 2 h / 20 °C View Scheme
参考文献
Howell, Lesley A.; Bowater, Richard A.; O'Connell, Maria A.; Reszka, Anthony P.; Neidle, Stephen; Searcey, Mark
ChemMedChem, 2012 , vol. 7, # 5 p. 792 - 804
反应条件
sodium dithionite; water in dimethyl sulfoxide T=20°C; pH=7.4; phosphate buffer; Kinetics; Concentration;
参考文献
Leriche, Geoffray; Budin, Ghyslain; Brino, Laurent; Wagner, Alain
European Journal of Organic Chemistry, 2010 , # 23 p. 4360 - 4364
反应条件
acetic acid in ethanol 4 h; Heating;
参考文献
Reisch, J.; Usifoh, C. O.; Oluwadiya, J. O.
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 1953 - 1956
反应条件
triethylamine in benzene
T=20 - 40°C;
参考文献
Twin, Heather; Batey, Robert A.
Organic Letters, 2004 , vol. 6, # 26 p. 4913 - 4916
反应条件
1.1: 68 percent / Et3N / benzene / 20 - 40 °C
2.1: 89 percent / Ph3P; Huenig's base / CH2Cl2 / 5 h / 20 °C
3.1: piperidine / ethyl acetate / 1 h / 20 °C
3.2: 85 percent / SiO2 / ethyl acetate
View Scheme
参考文献
Twin, Heather; Batey, Robert A.
Organic Letters, 2004 , vol. 6, # 26 p. 4913 - 4916
反应条件
1.1: 68 percent / Et3N / benzene / 20 - 40 °C
2.1: 89 percent / Ph3P; Huenig's base / CH2Cl2 / 5 h / 20 °C
3.1: piperidine / ethyl acetate / 1 h / 20 °C
3.2: 85 percent / SiO2 / ethyl acetate
4.1: 83 percent / NaOH; H2O / tetrahydrofuran / 2 h / 20 °C
5.1: 78 percent / Dess-Martin periodinane; pyridine / CH2Cl2 / 5 h / 0 - 20 °C
View Scheme
参考文献
Twin, Heather; Batey, Robert A.
Organic Letters, 2004 , vol. 6, # 26 p. 4913 - 4916
反应条件
1.1: 68 percent / Et3N / benzene / 20 - 40 °C
2.1: 89 percent / Ph3P; Huenig's base / CH2Cl2 / 5 h / 20 °C
3.1: piperidine / ethyl acetate / 1 h / 20 °C
3.2: 85 percent / SiO2 / ethyl acetate
4.1: 83 percent / NaOH; H2O / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Twin, Heather; Batey, Robert A.
Organic Letters, 2004 , vol. 6, # 26 p. 4913 - 4916
