5-甲基-1H-吡咯并[3,2-b]吡啶合成路线 （共 9 条）
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium carbonate in ethylene glycol diethyl ether T=120°C; 1 h; Inert atmosphereMicrowave irradiation;
参考文献
Almirall, S.A.; Vidal Juan, Bernat; Alonso Diez, Juan Antonio; Buil Albero, María Antonia; Eastwood, Paul Robert; Esteve Trias, Cristina; Lozoya Toribio, María Estrella; Roberts, Richard Spurring; Vidal Gispert, Laura
Patent: EP2548876 A1, 2013 ;
Location in patent: Paragraph 0287-0290 ;
EP 2548876 A1
反应条件
in tetrahydrofuran; water
参考文献
Pfizer Inc.
Patent: US5051412 A1, 1991 ;
反应条件
1: sodium hydroxide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 24 h / 65 °C / |Inert atmosphere 2: hydrogenchloride / methanol / 21 h / 75 °C 3: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / ethylene glycol diethyl ether / 1 h / 120 °C / |Inert atmosphere; |Microwave irradiation View Scheme
参考文献
Almirall, S.A.; Vidal Juan, Bernat; Alonso Diez, Juan Antonio; Buil Albero, María Antonia; Eastwood, Paul Robert; Esteve Trias, Cristina; Lozoya Toribio, María Estrella; Roberts, Richard Spurring; Vidal Gispert, Laura
Patent: EP2548876 A1, 2013 ;
EP 2548876 A1
反应条件
1: hydrogenchloride / methanol / 21 h / 75 °C 2: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / ethylene glycol diethyl ether / 1 h / 120 °C / |Inert atmosphere; |Microwave irradiation View Scheme
参考文献
Almirall, S.A.; Vidal Juan, Bernat; Alonso Diez, Juan Antonio; Buil Albero, María Antonia; Eastwood, Paul Robert; Esteve Trias, Cristina; Lozoya Toribio, María Estrella; Roberts, Richard Spurring; Vidal Gispert, Laura
Patent: EP2548876 A1, 2013 ;
EP 2548876 A1
反应条件
1: N-iodo-succinimide / N,N-dimethyl-formamide / 16 h / 20 °C 2: sodium hydroxide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 24 h / 65 °C / |Inert atmosphere 3: hydrogenchloride / methanol / 21 h / 75 °C 4: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / ethylene glycol diethyl ether / 1 h / 120 °C / |Inert atmosphere; |Microwave irradiation View Scheme
参考文献
Almirall, S.A.; Vidal Juan, Bernat; Alonso Diez, Juan Antonio; Buil Albero, María Antonia; Eastwood, Paul Robert; Esteve Trias, Cristina; Lozoya Toribio, María Estrella; Roberts, Richard Spurring; Vidal Gispert, Laura
Patent: EP2548876 A1, 2013 ;
EP 2548876 A1
反应条件
sodium ethanolate T=210°C;
参考文献
Clayton; Kenyon
Journal of the Chemical Society, 1950 , p. 2952,2955
反应条件
1: Raney nickel; ethanol / 70 °C / 73550.8 Torr / Hydrogenation 3: sodium ethylate / 210 °C View Scheme
参考文献
Clayton; Kenyon
Journal of the Chemical Society, 1950 , p. 2952,2955
反应条件
2: sodium ethylate / 210 °C View Scheme
参考文献
Clayton; Kenyon
Journal of the Chemical Society, 1950 , p. 2952,2955
反应条件
1: With copper(ll) bromide in acetonitrile T=20°C; 1 h; 2: With ammonium hydroxide in methanol; acetonitrile T=20°C; 0.5 h;
参考文献
Almirall, S.A.; Vidal Juan, Bernat; Alonso Diez, Juan Antonio; Buil Albero, María Antonia; Eastwood, Paul Robert; Esteve Trias, Cristina; Lozoya Toribio, María Estrella; Roberts, Richard Spurring; Vidal Gispert, Laura
Patent: EP2548876 A1, 2013 ;
Location in patent: Paragraph 0291-0294 ;
EP 2548876 A1
