2-(3-吡啶基)1H-吡咯合成路线 （共 12 条）
反应条件
ammonium acetate in ethanol Paal-Knoor reaction;
参考文献
Vega, Ismael El Drubi; Gale, Philip A.; Light, Mark E.; Loeb, Stephen J.
Chemical Communications, 2005 , # 39 p. 4913 - 4915
反应条件
potassium hydroxide in dimethyl sulfoxide T=80 - 85°C; Trofimov reaction; P=9120 - 10640 Torr; 3.5 h;
参考文献
Afonin; Ushakov; Petrova; Sobenina; Mikhaleva; Voronov; Trofimov
Russian Journal of Organic Chemistry, 2000 , vol. 36, # 7 p. 1043 - 1049
反应条件
caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; bis (triortho-tolylphosphine)palladium(II) chloride T=150°C; 4 h;
参考文献
Romero; Harrak; Basset; Ginet; Constans; Pujol
Tetrahedron, 2006 , vol. 62, # 38 p. 9010 - 9016
反应条件
1.1: Mg / tetrahydrofuran / 1 h / 20 °C 1.2: Amberlite IRC-50 / tetrahydrofuran 2.1: 73 percent / Amberlyst 15; Et3N / CH2Cl2 / 2 h / 20 °C 3.1: 84 percent / ammonium acetate / ethanol View Scheme
参考文献
Kruse, Chris G.; Bouw, Jan P.; Hes, Roelof van; Kuilen, Aalt van de; Hartog, Jack A. J. den
Heterocycles, 1987 , vol. 26, # 12 p. 3141 - 3151
反应条件
1: 73 percent / Amberlyst 15; Et3N / CH2Cl2 / 2 h / 20 °C 2: 84 percent / ammonium acetate / ethanol View Scheme
参考文献
Kruse, Chris G.; Bouw, Jan P.; Hes, Roelof van; Kuilen, Aalt van de; Hartog, Jack A. J. den
Heterocycles, 1987 , vol. 26, # 12 p. 3141 - 3151
反应条件
1: 72 percent / Na2CO3, H2O / Pd(PPh3)4 / 1,2-dimethoxy-ethane / Heating 2: NaOMe / methanol / Ambient temperature View Scheme
参考文献
Johnson, Christopher N.; Stemp, Geoffrey; Anand, Neel; Stephen, Susanna C.; Gallagher, Timothy
Synlett, 1998 , # 9 p. 1025 - 1027
反应条件
1.1: 54 percent / DCC; Et3N / CH2Cl2 / 0 - 20 °C 2.1: Mg / tetrahydrofuran / 1 h / 20 °C 2.2: Amberlite IRC-50 / tetrahydrofuran 3.1: 73 percent / Amberlyst 15; Et3N / CH2Cl2 / 2 h / 20 °C 4.1: 84 percent / ammonium acetate / ethanol View Scheme
参考文献
Vega, Ismael El Drubi; Gale, Philip A.; Light, Mark E.; Loeb, Stephen J.
Chemical Communications, 2005 , # 39 p. 4913 - 4915
反应条件
sodium hydroxide; phosphorus tribromide 2.) H2O, dioxane; Yield given. Multistep reaction;
参考文献
Saeki, Seitaro; Hayashi, Takaaki; Hamana, Masatomo
Heterocycles, 1984 , vol. 22, # 3 p. 545 - 548
反应条件
1: amyl nitrite / acetic acid 2: 1.) PBr3, 2.) NaOH / 2.) H2O, dioxane View Scheme
参考文献
Saeki, Seitaro; Hayashi, Takaaki; Hamana, Masatomo
Heterocycles, 1984 , vol. 22, # 3 p. 545 - 548
反应条件
1.1: ethanol / Heating 1.2: n-BuLi / -78.15 °C 2.1: TFA / tetrahydrofuran; H2O 2.2: NH4OAc / ethanol / Heating View Scheme
参考文献
Noland, Wayland E.; Britton, Doyle
Acta Crystallographica Section C: Crystal Structure Communications, 2003 , vol. 59, # 5 p. o263-o267
