达诺司坦合成路线

参考文献

CALITHERA BIOSCIENCES INC.; LI, Jim; CHEN, Lijing; GOYAL, Bindu; LAIDIG, Guy; STANTON, Timothy, Friend; SJOGREN, Eric, Brian
Patent: WO2013/78123 A1, 2013 ;
Location in patent: Page/Page column 56; 57 ;
WO 2013/078123 A1

590-92-13-溴丙酸+

68-11-1巯基乙酸

4938-00-5达诺司坦

参考文献

Schoeberl; Lange
Justus Liebigs Annalen der Chemie, 1956 , vol. 599, p. 140,152
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Challenger; Hollingworth
Journal of the Chemical Society, 1959 , p. 61,66

141-76-43-碘丙酸+

68-11-1巯基乙酸

4938-00-5达诺司坦

参考文献

Karrer; Schmid
Helvetica Chimica Acta, 1944 , vol. 27, p. 124,126
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Schoeberl
Chemische Berichte, 1947 , vol. 80, p. 381,384
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Larsson; Joensson
Chemische Berichte, 1934 , vol. 67, p. 759

1119-62-63,3′-二硫代二丙酸

4938-00-5达诺司坦

参考文献

Loven
Chemische Berichte, 1896 , vol. 29, p. 1133,1135

57-57-8β-丙内酯+

623-51-8巯基乙酸乙酯

4938-00-5达诺司坦

参考文献

Goodrich Co.
Patent: US2449992 , 1945 ;

68-11-1巯基乙酸+

292638-85-8丙烯酸甲酯

4938-00-5达诺司坦