3-(苄氧基)环丁烷羧酸甲酯合成路线 （共 13 条）
反应条件
hydrogen; platinum(IV) oxide in methanol 7 h;
参考文献
Safanda; Sobotka
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 9 p. 2440 - 2447
反应条件
1: 85 percent / H2 / PtO2 / methanol / 7 h 2: 88 percent / pyridine / 336 h 3: 80 percent / NH4Br, NH3 / 144 h / Ambient temperature 4: 59 percent / NaN3 / methanol; H2O / 20 h / Heating 5: 81 percent / H2 / PtO2 / methanol / 6 h / Ambient temperature 6: 79 percent / HCl / H2O / 20 h / Heating View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 47, # 9 p. 2440 - 2447
反应条件
1: 85 percent / H2 / PtO2 / methanol / 7 h 2: 88 percent / pyridine / 336 h 3: 1. NH4Br, NH3; 2. HCl / 1. 88 deg C, 16 h; 2. H2O, 88 deg C, 20 h, heating View Scheme
参考文献
Safanda; Sobotka
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 9 p. 2440 - 2447
反应条件
1: 85 percent / H2 / PtO2 / methanol / 7 h 2: 88 percent / pyridine / 336 h 3: 1. NH4Br, NH3; 2. HCl / 1. 88 deg C, 16 h; 2. H2O, 88 deg C, 20 h, heating View Scheme
参考文献
Safanda; Sobotka
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 9 p. 2440 - 2447
反应条件
sulfuric acid in chloroform
16 h; Heating;
参考文献
Safanda; Sobotka
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 9 p. 2440 - 2447
反应条件
1: 30 percent / sodium ethoxide / ethanol / 42 h / Heating
2: 92 percent / KOH / aq. ethanol / 1.5 h / Heating
3: 83 percent / 1. 150 deg C, 1 h, 4.0E3 Pa; 2. 165 deg C, 2.5 h; 3. 180 deg C, 2.5 h
4: 81 percent / H2SO4 / CHCl3 / 16 h / Heating
View Scheme
参考文献
Safanda; Sobotka
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 9 p. 2440 - 2447
反应条件
1: 92 percent / KOH / aq. ethanol / 1.5 h / Heating
2: 83 percent / 1. 150 deg C, 1 h, 4.0E3 Pa; 2. 165 deg C, 2.5 h; 3. 180 deg C, 2.5 h
3: 81 percent / H2SO4 / CHCl3 / 16 h / Heating
View Scheme
参考文献
Safanda; Sobotka
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 9 p. 2440 - 2447
反应条件
1: (i) KOH, aq. EtOH, (ii) (decarboxylation)
2: H2SO4 / 1,2-dichloro-ethane
View Scheme
参考文献
Wiberg,K.B. et al.
Tetrahedron, 1965 , vol. 21, p. 2749 - 2769
反应条件
1: mercury dichloride / |Inert atmosphere
2: sodium methylate / |Inert atmosphere
3: potassium hydroxide / ethanol / |Inert atmosphere
4: hydrogenchloride / |Inert atmosphere
View Scheme
参考文献
Slade, Joel; Bajwa, Joginder; Liu, Hui; Parker, David; Vivelo, James; Chen, Guang-Pei; Calienni, John; Villhauer, Edwin; Prasad, Kapa; Repic, Oljan; Blacklock, Thomas J.
Organic Process Research and Development, 2007 , vol. 11, # 5 p. 825 - 835
反应条件
1: sodium methylate / |Inert atmosphere
2: potassium hydroxide / ethanol / |Inert atmosphere
3: hydrogenchloride / |Inert atmosphere
View Scheme
参考文献
Slade, Joel; Bajwa, Joginder; Liu, Hui; Parker, David; Vivelo, James; Chen, Guang-Pei; Calienni, John; Villhauer, Edwin; Prasad, Kapa; Repic, Oljan; Blacklock, Thomas J.
Organic Process Research and Development, 2007 , vol. 11, # 5 p. 825 - 835
