1: formic acid With acetic anhydride in ethyl acetate
T=45 - 46°C; 0.583333 h; Inert atmosphere;
2: 3-methyl-2-amino-pyridine in ethyl acetate
T=20 - 48°C; 7 h;
参考文献
E. I. du Pont de Nemours and Company; HOLYOKE JR, Caleb, William; TONG, My-Hanh, Thi; ZHANG, Wenming
Patent: WO2012/106495 A1, 2012 ;
Location in patent: Page/Page column 47-48 ;
1: With tert.-butyl lithium in diethyl ether; pentane
T=-78 - -30°C; 5 h; Inert atmosphere;
2: With N,N-dimethyl-formamide in diethyl ether; pentane
T=-30°C; 0.166667 h; Inert atmosphere;
参考文献
Van Zandt, Michael C.; Doan, Brian; Sawicki, Diane R.; Sredy, Janet; Podjarny, Alberto D.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 7 p. 2006 - 2008
