6,7-二甲氧基-3,4-二氢-异喹啉-1-酮合成路线 （共 37 条）
反应条件
1: 54 percent / phosphoruspentasulphide / pyridine / 2.5 h / Heating 2: 60 percent / CH2Cl2 / 2 h / Heating View Scheme
参考文献
Sharma, S. D.; Mehra, Usha; Gupta, P. K.
Tetrahedron, 1980 , vol. 36, p. 3427 - 3430
反应条件
diphosphorus pentasulfide in pyridine 2.5 h; Heating;
参考文献
Sharma, S. D.; Mehra, Usha; Gupta, P. K.
Tetrahedron, 1980 , vol. 36, p. 3427 - 3430
反应条件
1: 75 percent / sodium hydride / benzene 2: 5 percent / methionine; methanesulphonic acid / neat (no solvent) 3: lithium aluminium hydride / tetrahydrofuran View Scheme
参考文献
Irie, Hiroshi; Shiina, Ayako; Fushimi, Tamaki; Katakawa, Jun'ichi; Fujii, Nobutaka; Yajima, Haruaki
Chemistry Letters, 1980 , p. 875 - 878
反应条件
bis-trimethylsilyl ether; phosphorous pentoxide; trichlorophosphate
T=150°C; 0.666667 h; Microwave irradiation;
参考文献
Awuah, Emelia; Capretta, Alfredo
Journal of Organic Chemistry, 2010 , vol. 75, # 16 p. 5627 - 5634
反应条件
hydrogenchloride; sodium azide in water
T=0 - 20°C;
参考文献
Abate, Carmen; Selivanova, Svetlana V.; Mueller, Adrienne; Kraemer, Stefanie D.; Schibli, Roger; Marottoli, Roberta; Perrone, Roberto; Berardi, Francesco; Niso, Mauro; Ametamey, Simon M.
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 920 - 930
反应条件
acetic acid in water; toluene
T=120°C; 14 h;
参考文献
Presset, Marc; Oehlrich, Daniel; Rombouts, Frederik; Molander, Gary A.
Organic Letters, 2013 , vol. 15, # 7 p. 1528 - 1531
反应条件
1: chloroformic acid 4-nitrophenyl ester With resin-CH2-OH; N-ethyl-N,N-diisopropylamine in dichloromethane
2: 2-(3,4-dimethoxyphenyl)-ethylamine With N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
3: With phosphorus pentoxide
T=80°C; 12 h; Further stages.;
参考文献
Chern, Meei-Shiou; Li, Wen-Ren
Tetrahedron Letters, 2004 , vol. 45, # 45 p. 8323 - 8326
反应条件
sodium methylate in ethanol
3 h; Ambient temperature;
参考文献
Venkov; Statkova-Abeghe
Tetrahedron, 1996 , vol. 52, # 4 p. 1451 - 1460
反应条件
hydrogenchloride in 1,4-dioxane
0.5 h; Heating;
参考文献
Kawase, Masami
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 8 p. 1248 - 1253
反应条件
phosphoric acid in dichloromethane
2 h; Ambient temperature; Yield given;
参考文献
Umezawa; Hoshino; Sawaki; Mori
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 3 p. 1003 - 1005
