N,N-二甲基吡啶-2,5-二胺合成路线 （共 6 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol; ethyl acetate T=20°C; P=2327.23 Torr; 1.5 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/4117 A1, 2008 ;
Location in patent: Page/Page column 112 ;
反应条件
Pd/C; ammonium formate in methanol
参考文献
Nara, Susheel J.; Jha, Mukund; Brinkhorst, Johan; Zemanek, Tony J.; Pratt, Derek A.
Journal of Organic Chemistry, 2008 , vol. 73, # 23 p. 9326 - 9333
反应条件
1: concentrated sulfuric acid; nitric acid / <5 2: tin; concentrated hydrochloric acid View Scheme
参考文献
QUEEN'S UNIVERSITY AT KINGSTON; UNIVERSITA DI BOLOGNA; PRATT, Derek A.; HANTHORN, Jason, J.; VALGIMIGLI, Luca
Patent: WO2012/162818 A1, 2012 ;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/40522 A1, 2006 ;
Location in patent: Page/Page column 87 ;
WO 2006/040522 A1
反应条件
1.1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / Inert atmosphere 1.2: 80 °C / Inert atmosphere 2.1: 10 palladium on activated charcoal; ammonium formate / methanol / Reflux View Scheme
参考文献
Hanthorn, Jason J.; Valgimigli, Luca; Pratt, Derek A.
Journal of Organic Chemistry, 2012 , vol. 77, # 16 p. 6908 - 6916
参考文献
Tschitschibabin; Knunjanz
Chemische Berichte, 1929 , vol. 62, p. 3050
