3-甲氧基-2-硝基苯甲酸合成路线 （共 46 条）
反应条件
1: 97 percent / H2, aq. NaHCO3 / Pd/C
2: K2CO3, Cu, CuBr, N-methylpyrrolidinone / 2-ethoxy-ethanol / 2 h / 150 °C
View Scheme
参考文献
Denny; Atwell; Baguley
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 363 - 367
反应条件
1: platinum; ethanol / Hydrogenation
2: aqueous sulfuric acid; sodium nitrite / Eintragen der erhaltenen Diazoniumsalz-Loesung in eine heisse wss. Loesung von Kaliumjodid
View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
1: Py*HCl / 180 - 190 °C
3: Na2S2O4*H2O, NaOH
4: (i) H2SO4, aq. NaNO2, (ii) aq. KI
5: SOCl2
View Scheme
参考文献
Cleaver,L. et al.
Australian Journal of Chemistry, 1976 , vol. 29, p. 2003 - 2021
反应条件
1: 100 percent / H2 / 10percent Pd/C / ethanol / 0.17 h / 2625.2 Torr / Ambient temperature
2: 58 percent / aq. AcOH / 2 h
View Scheme
参考文献
Ife, Robert J.; Brown, Thomas H.; Blurton, Peter; Keeling, David J.; Leach, Colin A.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 14 p. 2763 - 2773
反应条件
1: Py*HCl / 180 - 190 °C
3: Na2S2O4*H2O, NaOH
View Scheme
参考文献
Cleaver,L. et al.
Australian Journal of Chemistry, 1976 , vol. 29, p. 2003 - 2021
反应条件
1: Py*HCl / 180 - 190 °C
3: Na2S2O4*H2O, NaOH
4: (i) H2SO4, aq. NaNO2, (ii) aq. KI
View Scheme
参考文献
Cleaver,L. et al.
Australian Journal of Chemistry, 1976 , vol. 29, p. 2003 - 2021
