3-甲氧基-2-硝基苯甲酸合成路线 （共 46 条）
反应条件
1: SOCl2 / CH2Cl2 / 2 h / Heating 2: aq. NH3 / tetrahydrofuran / 0.5 h / Ambient temperature 3: 74.5 percent / SOCl2 / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Kimura; Watanabe; Matsui; Hayashi; Tanaka; Ohtsuka; Saeki; Kogushi; Kabayashi; Akasaka; Yamagishi; Saitou; Yamatsu
Journal of Medicinal Chemistry, 1993 , vol. 36, # 11 p. 1641 - 1653
反应条件
1: platinum; ethanol / Hydrogenation 2: aqueous sulfuric acid; sodium nitrite / Eintragen der erhaltenen Diazoniumsalz-Loesung in eine heisse wss. Loesung von Kaliumjodid 3: sulfuric acid View Scheme
参考文献
Stanley; McMahon; Adams
Journal of the American Chemical Society, 1933 , vol. 55, p. 706,712
反应条件
1.1: thionyl chloride / 3 h / 75 °C 2.1: diethyl ether; ethanol / 20 °C / Reflux 2.2: 18 h / Reflux View Scheme
参考文献
H. LUNDBECK A/S; KEHLER, Jan; KILBURN, John Paul; NIELSEN, Jacob; PÜSCHL, Ask; LANGGÅRD, Morten; JESSING, Mikkel; MARIGO, Mauro
Patent: WO2013/50527 A1, 2013 ;
反应条件
1: 100 percent / H2 / 10percent Pd/C / ethanol / 0.17 h / 2625.2 Torr / Ambient temperature 2: 58 percent / aq. AcOH / 2 h 3: 87 percent / POCl3, N,N-dimethylaniline / 5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 14 p. 2763 - 2773
反应条件
1: SOCl2 / CH2Cl2 / 2 h / Heating 2: aq. NH3 / tetrahydrofuran / 0.5 h / Ambient temperature 3: 74.5 percent / SOCl2 / tetrahydrofuran / Ambient temperature 4: 87.5 percent / H2 / 10percent Pd/C / ethyl acetate / 2 h / 760 Torr View Scheme
参考文献
Kimura; Watanabe; Matsui; Hayashi; Tanaka; Ohtsuka; Saeki; Kogushi; Kabayashi; Akasaka; Yamagishi; Saitou; Yamatsu
Journal of Medicinal Chemistry, 1993 , vol. 36, # 11 p. 1641 - 1653
反应条件
ammonium hydroxide T=180°C; im zugeschmolzenen Rohr;
参考文献
Chemische Berichte, , vol. 22, p. 2354
参考文献
Chemische Berichte, , vol. 22, p. 2354
反应条件
1: B2H6 / tetrahydrofuran
2: H2 / 10percent Pd/C / ethyl acetate / 1 h / 760 Torr
View Scheme
参考文献
Kimura; Watanabe; Matsui; Hayashi; Tanaka; Ohtsuka; Saeki; Kogushi; Kabayashi; Akasaka; Yamagishi; Saitou; Yamatsu
Journal of Medicinal Chemistry, 1993 , vol. 36, # 11 p. 1641 - 1653
反应条件
1: 1.) Et3N, diphenyl phosphorazidate / 1.) benzene, reflux, 40 min, 2.) benzene, 40 min
2: 29.9 percent / LiAlH4 / tetrahydrofuran / 1.5 h / 0 - 20 °C
3: 1.) 4 N HCl, 2.) 28percent aq. NH3 / 1.) reflux, 4 h
View Scheme
参考文献
Abe, Yoshito; Kayakiri, Hiroshi; Satoh, Shigeki; Inoue, Takayuki; Sawada, Yuki; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Sawai, Hiroe; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 21 p. 4062 - 4079
反应条件
1: 97 percent / H2, aq. NaHCO3 / Pd/C
2: 73 percent / diazotization
View Scheme
参考文献
Pschorr
Justus Liebigs Annalen der Chemie, 1912 , vol. 391, p. 44
